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Probióticos – revisão bibliográfica e perspetivas futuras
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| PPG_36444 | 801.4 KB | Adobe PDF |
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Abstract(s)
O microbiota intestinal, conjunto de comunidades microbianas que colonizam o trato gastrointestinal, mantém uma relação de simbiose com o hospedeiro e está envolvido em processos essenciais para a manutenção da sua saúde. Alterações na composição e função deste complexo sistema resultam no desenvolvimento de patologias. Assim, a modulação do microbiota pode ser importante para a prevenção da doença e mesmo ser utilizada como adjuvante em terapêutica.
A evolução tecnológica permitiu investigar com mais detalhe a composição do microbiota e a sua relação com o hospedeiro, permitindo desenvolver novas abordagens terapêuticas para o tratamento de doenças multifatoriais e emergentes. De acordo com a Food and Agriculture Organization (FAO) e a Organização Mundial de Saúde (OMS), os probióticos são “microrganismos vivos que, quando administrados em quantidades adequadas, conferem benefícios à saúde do hospedeiro”.
Os efeitos benéficos dos probióticos são diversos. Através da modulação do microbiota, modulam a resposta imunitária, são responsáveis pelo reforço da barreira epitelial intestinal e têm influência noutros órgãos do organismo. A sua administração tem uma vasta utilização no tratamento e prevenção de patologias gastrointestinais, podendo também ser utilizada no contexto de patologias em diferentes sistemas.
Esta dissertação tem como objetivo realizar uma revisão bibliográfica do conhecimento científico atual sobre o papel dos probióticos na saúde humana, relacionando-o com a composição do microbiota e abordando os mecanismos pelos quais exercem efeitos benéficos em patologias diversas.
The intestinal microbiota, a group of microbial communities that colonize the gastrointestinal tract, maintains a symbiotic relationship with the host and is involved in essential processes for maintaining health. Changes in the composition and function of this complex system result in the development of diseases. So, microbiota modulation may be important for disease prevention and also be used as a therapeutic adjuvant. Technical advances allowed to investigate in more detail the composition of the microbiota and its relationship with the host, resulting in the development of new therapeutic approaches for the treatment of multifactorial and emerging diseases. Probiotics, according to the Food and Agriculture Organization (FAO) and the World Health Organization (WHO), are “live microorganisms that, when administered in adequate amounts, confer benefits to the host”. The beneficial effects of probiotics are diverse. Through modulation of the microbiota, probiotics modulate the immune response, are responsible for strengthening the intestinal epithelial barrier and also impact the function of diverse organs of the body. Its administration has a wide use in the treatment and prevention of gastrointestinal pathologies and may also be used for the treatment pathologies that affect other systems. The aim of this dissertation is to carry out a bibliographic review of the current scientific knowledge on the role of probiotics in human health, relating it to the microbiota composition and also approach the mechanisms by which they exert beneficial effects in different pathologies.
The intestinal microbiota, a group of microbial communities that colonize the gastrointestinal tract, maintains a symbiotic relationship with the host and is involved in essential processes for maintaining health. Changes in the composition and function of this complex system result in the development of diseases. So, microbiota modulation may be important for disease prevention and also be used as a therapeutic adjuvant. Technical advances allowed to investigate in more detail the composition of the microbiota and its relationship with the host, resulting in the development of new therapeutic approaches for the treatment of multifactorial and emerging diseases. Probiotics, according to the Food and Agriculture Organization (FAO) and the World Health Organization (WHO), are “live microorganisms that, when administered in adequate amounts, confer benefits to the host”. The beneficial effects of probiotics are diverse. Through modulation of the microbiota, probiotics modulate the immune response, are responsible for strengthening the intestinal epithelial barrier and also impact the function of diverse organs of the body. Its administration has a wide use in the treatment and prevention of gastrointestinal pathologies and may also be used for the treatment pathologies that affect other systems. The aim of this dissertation is to carry out a bibliographic review of the current scientific knowledge on the role of probiotics in human health, relating it to the microbiota composition and also approach the mechanisms by which they exert beneficial effects in different pathologies.
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Keywords
Probióticos Microbiota Probióticos de próxima geração Probiotics Microbiota Next generation probiotics