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Publication
Pancreatite alcoĆ³lica
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Authors
Advisor(s)
Abstract(s)
A pancreatite alcoĆ³lica Ć© uma das principais complicaƧƵes do consumo excessivo de
Ć”lcool. O risco de desenvolver a doenƧa aumenta com a ingestĆ£o de doses crescentes de
Ć”lcool, sugerindo que os efeitos tĆ³xicos estĆ£o relacionados com a quantidade de Ć”lcool
ingerida.
No entanto, apenas uma minoria dos alcoĆ³licos desenvolve pancreatite, o que indica a
necessidade de um fator desencadeador adicional para iniciar a lesĆ£o pancreĆ”tica
clinicamente evidente.
A pancreatite alcoĆ³lica comeƧa como um processo agudo necroinflamatĆ³rio/
autodigestivo, progredindo com repetidos episĆ³dios de necroinflamaĆ§Ć£o. O seu espectro
clĆnico inclui pancreatite aguda (dor abdominal aguda e elevados nĆveis sĆ©ricos das
enzimas pancreĆ”ticas) e pancreatite crĆ³nica (dor abdominal, mĆ” digestĆ£o e diabetes).
TĆŖm sido feitos avanƧos significativos que fornecem uma visĆ£o sobre os mecanismos
moleculares da lesĆ£o pancreĆ”tica provocada pelo Ć”lcool, principalmente no que diz
respeito aos seus efeitos tĆ³xicos sobre as cĆ©lulas acinares pancreĆ”ticas e recentemente,
nas cƩlulas estreladas pancreƔticas (PSCs), que desempenham um papel fundamental na
fibrose, caraterĆstica da pancreatite crĆ³nica alcoĆ³lica. Alcoholic pancreatitis is a major complication of alcohol abuse. The risk of developing
pancreatitis increases with increasing doses of alcohol, suggesting that alcohol exerts
dose-related toxic effects on the pancreas.
However, it is also clear that only a minority of alcoholics develop the disease,
indicating that an additional trigger may be required to initiate clinically evident
pancreatic injury.
Alcoholic pancreatitis is thought to begin as an acute necroinflammatory/autodigestive
process in a susceptible individual and to progress with repeated episodes. The clinical
spectrum of the disease includes acute pancreatitis (acute abdominal pain and raised
sƩrum levels of pancreatic enzymes) and chronic pancreatitis (abdominal pain,
maldigestion, diabetes).
Significant advances have been made in recent years that provide an insight into the
molecular mechanisms of alcohol-related pancreatic injury, particularly with respect to
the direct toxic effects of alcohol on pancreatic acinar cells and on the recently
characterized PSCs, with may play a key role in the fibrosis of alcoholic chronic
pancreatitis.
Description
Projeto de PĆ³s-GraduaĆ§Ć£o/DissertaĆ§Ć£o apresentado Ć Universidade Fernando Pessoa como parte dos requisitos para obtenĆ§Ć£o do grau de Mestre em CiĆŖncias FarmacĆŖuticas
Keywords
Pancreatite alcoĆ³lica Efeitos tĆ³xicos CĆ©lulas acinares PSCs Fibrose pancreĆ”tica Alcoholic pancreatitis Toxic effects Acinar cells PSCs Pancreatic fibrosis