A carregar...
Publicação
Aplicação tópica dos canabinoides no controlo das lesões cutâneas
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| Projeto de pós-graduação_41081 | 1.48 MB | Adobe PDF |
Autores
Orientador(es)
Resumo(s)
O canabidiol (CBD), principal constituinte não psicotrópico da planta Cannabis sativa, tem sido objeto de intensa investigação devido ao seu potencial terapêutico em diversas patologias. A aplicação tópica de compostos canabinoides no tratamento de lesões cutâneas constitui o foco central deste trabalho de conclusão do Mestrado Integrado em Ciências Farmacêuticas. Embora a mortalidade associada a doenças cutâneas, como dermatite alérgica, psoríase e acne, não represente um foco predominante na população em geral, estas patologias exercem um impacto relevante na qualidade de vida e na autoestima dos doentes, afetando o bem-estar físico, emocional e social. A evidência científica sugere que a modulação do sistema endocanabinoide cutâneo é um alvo terapêutico promissor, destacando-se a capacidade do CBD para regular a resposta imunitária e diminuir a libertação de citocinas pró-inflamatórias. Para além disso, estudos recentes apontam para propriedades antioxidantes, sebostáticas e analgésicas do CBD, reforçando o seu potencial na abordagem de condições inflamatórias e dolorosas da pele. No entanto, apesar da investigação crescente nesta área, os mecanismos moleculares subjacentes a esta atividade ainda não se encontram totalmente elucidados, permanecendo necessária a realização de ensaios clínicos robustos que confirmem a eficácia e segurança do seu uso tópico. Por outro lado, a procura por terapêuticas de origem natural em dermatologia tem aumentado, motivada por questões de sustentabilidade ambiental e como estratégia para otimizar a terapêutica de doenças crónicas da pele, aliviando o encargo tanto para os doentes como para os sistemas de saúde. Neste contexto, a evolução do enquadramento legal da Cannabis abriu novas perspetivas para a investigação do uso de compostos canabinoides de aplicação tópica, constituindo uma oportunidade relevante para o desenvolvimento de formulações farmacêuticas inovadoras e seguras. Assim, este trabalho pretende contribuir para a compreensão do papel do CBD na terapêutica dermatológica, explorando os avanços científicos mais recentes, os desafios ainda existentes e as potencialidades futuras do seu uso como alternativa ou complemento às abordagens farmacológicas convencionais.
Cannabidiol (CBD), the main non-psychotropic constituent of the Cannabis sativa plant, has been the subject of intense investigation due to its therapeutic potential in a wide range of pathologies. The topical application of cannabinoid compounds in the treatment of skin lesions constitutes the central focus of this Master’s thesis in Pharmaceutical Sciences. Although mortality associated with skin diseases such as allergic dermatitis, psoriasis, and acne is not a predominant concern in the general population, these pathologies significantly impact patients’ quality of life and self-esteem, affecting physical, emotional, and social well-being. Scientific evidence suggests that modulation of the cutaneous endocannabinoid system is a promising therapeutic target, with CBD demonstrating the ability to regulate immune responses and reduce the release of pro-inflammatory cytokines. Furthermore, recent studies highlight its antioxidant, sebostatic, and analgesic properties, reinforcing its potential in the management of inflammatory and painful skin conditions. However, despite growing research in this field, the underlying molecular mechanisms have not yet been fully elucidated, and robust clinical trials remain necessary to confirm the efficacy and safety of its topical use. At the same time, the demand for natural-based therapeutics in dermatology has been increasing, driven by environmental sustainability concerns and by the need to optimize treatment strategies for chronic skin diseases, thereby reducing the burden both on patients and on healthcare systems. In this context, the evolution of the legal framework surrounding Cannabis has opened new perspectives for the investigation of cannabinoid compounds for topical application, representing a relevant opportunity for the development of innovative and safe pharmaceutical formulations. Thus, this work aims to contribute to a deeper understanding of the role of CBD in dermatological therapy, by exploring the latest scientific advances, the remaining challenges, and the future potential of its use as an alternative or complementary approach to conventional pharmacological treatments.
Cannabidiol (CBD), the main non-psychotropic constituent of the Cannabis sativa plant, has been the subject of intense investigation due to its therapeutic potential in a wide range of pathologies. The topical application of cannabinoid compounds in the treatment of skin lesions constitutes the central focus of this Master’s thesis in Pharmaceutical Sciences. Although mortality associated with skin diseases such as allergic dermatitis, psoriasis, and acne is not a predominant concern in the general population, these pathologies significantly impact patients’ quality of life and self-esteem, affecting physical, emotional, and social well-being. Scientific evidence suggests that modulation of the cutaneous endocannabinoid system is a promising therapeutic target, with CBD demonstrating the ability to regulate immune responses and reduce the release of pro-inflammatory cytokines. Furthermore, recent studies highlight its antioxidant, sebostatic, and analgesic properties, reinforcing its potential in the management of inflammatory and painful skin conditions. However, despite growing research in this field, the underlying molecular mechanisms have not yet been fully elucidated, and robust clinical trials remain necessary to confirm the efficacy and safety of its topical use. At the same time, the demand for natural-based therapeutics in dermatology has been increasing, driven by environmental sustainability concerns and by the need to optimize treatment strategies for chronic skin diseases, thereby reducing the burden both on patients and on healthcare systems. In this context, the evolution of the legal framework surrounding Cannabis has opened new perspectives for the investigation of cannabinoid compounds for topical application, representing a relevant opportunity for the development of innovative and safe pharmaceutical formulations. Thus, this work aims to contribute to a deeper understanding of the role of CBD in dermatological therapy, by exploring the latest scientific advances, the remaining challenges, and the future potential of its use as an alternative or complementary approach to conventional pharmacological treatments.
Descrição
Palavras-chave
Canabinoides Canabidiol Sistema endocanabinoide Lesões cutâneas Doenças inflamatórias da pele Aplicação tópica Cannabinoids Cannabidiol Endocannabinoid system Skin lesions Inflammatory skin diseases Topical application