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- Photodynamic therapy for the treatment of oral leukoplakia: systematic reviewPublication . Bokobza, Shaï Odelia Mazal; Oliveira, Filipa Pinto deBackground: Oral Leukoplakia is recognized as the most prevalent potentially malignant disorder, of the oral mucosa with significant variability in clinical presentation and risk of malignant transformation. Traditional treatment options often yield inconsistent results, and recurrence is frequent. Photodynamic Therapy has emerged as a non-invasive alternative with selective cytotoxicity, offering potential advantages and safety, efficacy, and aesthetic outcomes. Objective: This systematic review aims to evaluate the clinical impact of photodynamic therapy on the treatment of oral leukoplakia, focusing on the lesion response, recurrence, malignant transformation, and adverse effects. Methods: A comprehensive search was conducted across five databases (B-On, PubMed, Scielo, ScienceDirect, and Trip Database) using specific keywords and PRISMA guidelines. Twelve clinical studies met the inclusion criteria and were analyzed for protocol characteristics, patient demographics, and therapeutic outcomes. This systematic review is registered in PROSPERO with registration number CRD420251065255. Results: Photodynamic therapy demonstrated favorable complete remission rates, particularly when using 5-aminolevolunic acid as the photosensitizer. Lesion type, light source, photosensitizer delivery, and number of sessions influenced treatment outcomes. Recurrence and malignant transformation were reduced in several studies. Photodynamic therapy was generally well-tolerated with mild and transient side effects. Conclusion: Photodynamic therapy has a positive clinical impact on the treatment of oral leukoplakia, offering effective lesion control and a favorable safety profile. Its integration into oral medicine could benefit patients seeking minimally invasive and personalized therapeutic strategy, as photodynamic therapy is not only effective but also is generally painless, free of significant side effects, and without aesthetics compromise.
- Implicação da microbiota oral na doença de Alzheimer: revisão integrativaPublication . Ucar, Louis Mahmut; Coelho, Maria JoãoSenescência, corresponde ao processo fisiológico de envelhecimento que leva a uma lenta degradação das funções celulares. Quando o declínio diz respeito às funções cognitivas e comportamentais, falamos de demência. A doença de Alzheimer é a principal causa de demência e afeta aproximadamente 35 milhões de pessoas em todo o mundo. Esta doença neurodegenerativa afeta o tecido cerebral e leva a uma perda progressiva e irreversível das funções mentais, nomeadamente das funções cognitivas e de memória. A sua natureza universal, bem como as consequências socioeconómicas daí resultantes, fazem da doença de Alzheimer objeto de muita investigação científica. A cavidade oral acolhe uma microbiota de 700 espécies diferentes (bactérias, vírus e fungos) que constitui um reservatório inflamatório. Vários agentes infeciosos são suspeitos de desempenhar um papel etiológico na génese da inflamação e no agravamento de doenças neurodegenerativas, incluindo a doença de Alzheimer. Objetivo: Este trabalho tem como objetivo identificar a microbiota oral que pode estar associada ao desenvolvimento da doença de Alzheimer, avaliando o seu impacto no processo patológico da doença, através de uma revisão integrativa da literatura. Metodologia: Foi realizada uma pesquisa bibliográfica nas bases de dados PubMed e Science Direct, seguindo as diretrizes PRISMA. As referências foram triadas e selecionadas com base em critérios de elegibilidade, com artigos completos avaliados para inclusão e resumidos, tendo sido selecionados 11 artigos para este estudo. Resultados/Conclusão: A análise evidenciou que agentes infeciosos, como a bactéria Porphyromonas gingivalis, podem contribuir para a inflamação cerebral e o agravamento de doenças neurodegenerativas. Há indícios de ligação entre a periodontite e a doença de Alzheimer, embora ainda não haja comprovação de uma relação causal. Caso esta associação seja confirmada, a periodontite poderá ser considerada um fator de risco modificável, reforçando a importância da prevenção e tratamento dentário precoce para ajudar a reduzir a progressão da doença.
- The role of dentists in advising HPV vaccination for adults: a systematic review and meta-analysisPublication . Teixeira , Ana Rita Fernandes; Lopes, Otília; Bulhosa, José FriasHuman Papillomavirus (HPV) infection is a sexually transmitted disease that affects both genders, with an increasing number of infections being observed. To counter this rise, preventive measures, such as vaccination, are proposed. The current HPV vaccination rate remains below expectations. Considering the role dentists should play in primary prevention and advising on HPV infection, this systematic review aims to evaluate their role in counseling about HPV vaccination. The research question was developed using the PICO strategy: the Population corresponds to dentists, the Intervention consists of HPV vaccination counseling by dentists to adults, the Comparison refers to the absence of such counseling, and the Outcome is the adoption of a positive attitude by adults toward vaccination.It is expected that active involvement of dentists in counseling on HPV vaccination will lead to a positive attitude among adults towards primary prevention, potentially influencing vaccination uptake favorably. The aim of this review is to develop a clinical recommendation that demonstrates the essential role of dentists in counseling adults on HPV vaccination. The research was conducted in several databases, including PubMed, Cochrane Library, ScienceDirect, SciELO, Google Scholar, and the institutional repository of the University Fernando Pessoa, with no time restrictions and including publications in English, Portuguese, and Spanish. The search strategy included MeSH terms combined using Boolean connectors. To ensure transparency and reproducibility, the search protocol was registered on the PROSPERO platform. Two researchers will independently conduct the study selection using the Rayyan platform; a third researcher will intervene in case of disagreements. The screening process will follow PRISMA guidelines, and study quality will be assessed using the Joanna Briggs Institute tool. The lead researcher will be responsible for extracting relevant data, including primary data and main results, based on a pre-established analytical table. Data analysis will be conducted both qualitatively and quantitatively, allowing a comprehensive understanding of the existing evidence. Furthermore, the implications of the results for clinical practice and the importance of the dentist's role in promoting HPV vaccination will be discussed.