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Browsing by Author "Santos, Gory"

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  • Development and analytical characterization of ofloxacin ion-selective electrodes
    Publication . Souto, Renata; Pimenta, Adriana; Leal, Fernanda; Catarino, Rita; Santos, Gory; Tavares, Tânia
    An ofloxacin-selective electrode based on incorporation of a ofloxacin-tetrakis[3,5- bis(trifluoromethyl)phenyl]borate ion-pair complex in a poly(vinyl chloride) membrane was developed. The sensor displayed a Nernstian response over a wide concentration range (7×10-6–1×10-2 mol L-1) with a slope of 54.9 ± 1.3 mV per decade of concentration, a detection limit of 4×10-6 mol L-1 and adequate selectivity toward some inorganic and organic species. The sensor can be used for a period of more than 8 months without significant change in its characteristics. Desenvolveu-se um eléctrodo selectivo à ofloxacina, baseado no par iónico ofloxacina- -tetrakis[3,5-bis(trifluorometil)fenil]borato incorporado numa membrana de cloreto de polivinilo. O sensor apresenta uma resposta Nernstiana num alargado intervalo de concentrações (7×10-6–1×10-2 mol L-1), com um declive de 54,9±1,3 mV por década de concentração, um limite de detecção de 4×10-6 mol L-1 e adequada selectividade relativamente a algumas espécies orgânicas e inorgânicas. O seu tempo de vida é superior a oito meses, não havendo alteração das suas características durante este período.
    2010Journal article Open access Show more
  • Physical and chemical stimuli-responsive drug delivery systems: targeted delivery and main routes of administration
    Publication . Lopes, Joana R.; Santos, Gory; Barata, Pedro; Oliveira, Rita; Lopes, Carla Martins
    In the area of drug delivery, novel tools and technological approaches have captured the attention of researchers in order to improve the performance of conventional therapeutics and patient compliance to pharmacological therapy. Stimuli-responsive drug delivery systems (DDS) appear as a promising approach to control and target drug delivery. When these DDS are administered, the drug release is activated and then modulated through some action or external input and facilitated by the energy supplied externally. The stimuli responsible to activate the drug release can be classified into three types according to their nature or the type of energy applied: physical (e.g. magnetic field, electric field, ultrasound, temperature and osmotic pressure); chemical (e.g. pH, ionic strength and glucose); and biological (enzymes and endogenous receptors). The present review gives an overview of the most significant physical and chemical stimuliresponsive DDS and elucidates about their current and relevant applications in controlled and targeted drug delivery attending different routes of administration.
    2013Journal article Restricted access Show more