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- Sickle cell anemia and its impact on the oral cavity: integrative reviewPublication . C. Leal, M. Fernanda; Guimarães, Maria Inês; Natbeth, Ambre; Lopes Cardoso, InêsIntroduction: Sickle cell anemia, a hereditary disease, results from a mutation in the β-globin coding gene that makes up hemoglobin, leading to the deformation of erythrocytes. Numerous oral manifestations result from this disease; however, some may not be specific. Objectives: This study’s objective is to recognize these clinical manifestations of the disease to be able to manage oral health in sickle cell anemia patients. Methods: this integrative review analyzes scientific literature on the impact of sickle cell anemia on oral cavity. A bibliographic search was performed in PubMed, ScienceDirect, CINAHL Plus (via EBSCO host), Web of Science and Google Scholar databases using several combined keywords. The research question was: “What is the impact of sickle cell anemia on the oral cavity and dental treatments?”. Results: By applying the inclusion and exclusion criteria, 11 articles were included in this review. Conclusions: Studies show that the most common oral manifestations in these patients are periodontal disease and caries, although this association is not well understood.