Browsing by Author "Figueiras, Ana"
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- A administração na mucosa bucal como uma estratégia alternativa à via oralPublication . Dias, Sandra; Figueiras, Ana; Barata, Pedro; Oliveira, Rita; Santos, Delfim; Veiga, Franciscoo principal objectivo deste trabalho foi realizar uma revisão geral sobre o mecanismo de mucoadesão, tendo em consideração aspectos tais como, as teorias explicativas de tal mecanismo, assim como os passos envolvidos no mecanismo de acção. De seguida, foi feita uma abordagem sobre polímeros bioadesivos, tendo sido expostos alguns resultados práticos no sentido de avaliar a força bioadesiva, o trabalho bioadesivo, bem como índice de swelling, de forma a obter uma matriz mucoadesiva com características optimizadas.
- Preparation of supramolecular hydrogels containing poloxamers and methyl-β-cyclodextrinPublication . Garcia, Maria; Ruivo, Joana; Oliveira, Rita; Figueiras, AnaMeloxicam is a non-steroidal anti-inflammatory drug used in the treatment of rheumatoid arthritis, osteoarthritis and other inflammatory diseases. However, its prolonged use is associated to several side effects like gastrointestinal perforations, ulcerations and bleeding, probably due its low aqueous solubility and wettability after oral administration. These side effects can reduce patient compliance and discourage physician from prescribing this drug. In this way, inclusion complexes between meloxicam and methyl-β-cyclodextrin were prepared in aqueous solution by phase solubility studies and in solid state by freeze-drying method in order to increase drug solubility. The physicochemical characterization of the prepared complexes in solid state was performed by different techniques. Furthermore, hydrogels containing poloxamers were prepared for topical administration of meloxicam. For this purpose, solid inclusion complexes were incorporated in hydrogels with different poloxamers composition. The rheological behaviour of these formulations was studied by different methods and the drug release from optimised hydrogels was evaluated by Franz diffusion cells, applying some mathematical models to analyse the drug release mechanism from hydrogels. Results from phase solubility studies showed the formation of inclusion complexes between meloxicam and methyl-beta-cyclodextrin in aqueous solution in a 1:1 stoichiometry and an increase in drug solubility. Different techniques employed indicated complete formation of complexes in solid state prepared by the freeze-drying method. Moreover, the performed set of rheological studies, easily adapted to similar systems, demonstrated that hydrogels containing poloxamers and cyclodextrin may provide a suitable supramolecular platform for meloxicam delivery as a novel strategy to increase drug bioavailability.
- The main potentialities of resveratrol for drug delivery systemsPublication . Ruivo, Joana; Francisco, Cátia; Oliveira, Rita; Figueiras, AnaResveratrol (RSV), a natural polyphenol found in grapes, was found to be effective in the prevention and therapy of several diseases, however, it does have unfavourable physicochemical properties. In this context, an increasing number of studies have aimed at developing novel therapeutic systems for its delivery to overcome these disadvantages. This review focuses on the mechanisms of action and therapeutic applications. Finally, it also describes some tested formulations for RSV administration, controlled release and targeting, developed with the purpose of increasing RSV bioavailability.