FCS - Número 01 (2004)
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Browsing FCS - Número 01 (2004) by Author "Balcão, Victor"
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- Caracterização de modelos biomembranares (micelas e lipossomas) para a determinação de coeficientes de partiçãoPublication . Matos, Carla; Moutinho, Carla; Almeida, Cristina; Balcão, VictorA drug´s mechanism of action is dependent and related to its chemical structure and, in the bottom line, to the ability of the structure to interact with biological systems. The phospholipid composed cell membrane is a particularly important system for the pharmacological action of a drug, hence pharmacokinetic parameters are generally related with the drug/membrane interaction. This interaction is dependent on the hydrophilic/lipophilic balance of the drug, a parameter traditionally assessed by the organic solvent/water partition coefficient. Liposomes and micelles, due to their composition and physical organization, can constitute basic structural models for the cell membrane, being a precious tool in drug/membrane interaction studies. The use of these simpler models allows for the comprehension of basic processes, from which a progressive complexity can be added to the system, for a progressive insight of the involved phenomena. In this context, the determination of the liposome/water, or micelle/water partition coefficients, can constitute an indicative parameter of the drug´s real behaviour in the biological system.
- Moléculas anfifílicas - lípidos - e formação de agregados supramoleculares: micelas e lipossomasPublication . Moutinho, Carla; Matos, Carla; Almeida, Cristina; Balcão, VictorThe ability for self-organization of amphiphilic molecules (lipids), forming structurally more complex systems, from micelles to liposomes, constitutes the basic foundation for many biological phenomena. Lipids, for presenting important physiological roles, correlated with their particular structure and self-aggregation properties, are an interesting field of research and development. A detailed study of the micellar and membranar environment is fundamental to the knowledge of micelle´s and liposome´s capacity of acting as solubilization enhancers, what would allow the gathering of valuable information about drug´s mechanisms of transportation throw biomembranes. Assessment of the multiple amphiphilic molecule´s characteristics, together with the evaluation of the organized structures formed, is of the best interest for the comprehension of certain physiological functions, namely absorption, distribution and dynamics of certain compounds in the human organism.
- Processos automáticos de titulação baseados em sistemas discretos e de fluxo – evolução ao longo dos temposPublication . Moutinho, Carla; Matos, Carla; Almeida, Cristina; Balcão, VictorThe continuous necessity of create new analytical methods and to adapt them to the increasing demands of control and monitoring have promote the appearance and development of many areas of analytical chemistry, as well as the interest about automatization of methods of analysis. Automatic methods of analysis had assumed a great importance, namely, in clinical chemistry and in a level of the environmental control. The automatic needs pass, also, for the titrations, as a result of a crescent search for this king of analysis in samples of different origins. So, in this article is doing a revision about the titration systems (discrete and automatic) described, until date, in the literature.