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Bases genéticas envolvidas na reabsorção da crista residual mandibular - revisão narrativa
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| PPG_40038 | 383.52 KB | Adobe PDF |
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Abstract(s)
O aumento da longevidade do ser humano traduz-se no aparecimento de novos desafios para as
ciências da saúde. Como resultado do envelhecimento, as doenças crónicas e degenerativas
passaram a ocupar um papel predominante no desenvolvimento e na pesquisa clínica nas
últimas décadas. É o caso do estudo dos processos degenerativos que ocorrem na cavidade oral
após a perda de dentes. A reabsorção da crista residual mandibular é um processo amplamente
estudado desde meados do século passado e muitas pesquisas relacionam esse processo com
múltiplos fatores.
Este trabalho é uma revisão narrativa sobre as bases genéticas envolvidas na reabsorção da
crista residual mandibular. Foi estabelecida a relação entre alguns SPNs de alguns destes genes
e a RRR. As investigações apontam para a necessidade de realizar estudos com maior
amostragem que permitam ao clínico decidir o comportamento a tomar e impactar
positivamente a previsibilidade dos tratamentos com base na identificação de variações
genéticas.
The increase in life span of the human being leads to the appearance of new challenges for the health sciences. As a result of getting old, chronic and degenerative diseases started to occupy a predominant role in the development and clinical research in the last decades. It is the case of degenerative processes that occur in the oral cavity after teeth loss. Mandibular residual ridge resorption is a widely studied process from the middle of last century and many research relate this process with multiple factors. Recently, the understanding of the biological processes that occur after tooth extraction has been amplified. This work is a narrative revision concerning the genetic factors involved in mandibular residual ridge resorption (RRR). The relationship between some SNPs of some genes and RRR was stablished. All investigations point out for the need of studies with bigger sample sizes that allow the clinician to choose the best behaviour and have positive impact in treatments outcome based on the identification of genetic variations.
The increase in life span of the human being leads to the appearance of new challenges for the health sciences. As a result of getting old, chronic and degenerative diseases started to occupy a predominant role in the development and clinical research in the last decades. It is the case of degenerative processes that occur in the oral cavity after teeth loss. Mandibular residual ridge resorption is a widely studied process from the middle of last century and many research relate this process with multiple factors. Recently, the understanding of the biological processes that occur after tooth extraction has been amplified. This work is a narrative revision concerning the genetic factors involved in mandibular residual ridge resorption (RRR). The relationship between some SNPs of some genes and RRR was stablished. All investigations point out for the need of studies with bigger sample sizes that allow the clinician to choose the best behaviour and have positive impact in treatments outcome based on the identification of genetic variations.
Description
Keywords
Reabsorção da crista residual mandibular Fatores genéticos associados Polimorfismos de nucleotídeo único Mandibular residual ridge resorption Associated genetic factors Single nucleotide polymorphisms