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Exposure to fluoride: adverse outcome and toxicity in review
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| PPG_28999 | 555.21 KB | Adobe PDF |
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Abstract(s)
O flúor é amplamente utilizado em Medicina Dentária e a sua eficiência anticariogénica está bem estabelecida. Este trabalho tem como objetivo fazer uma revisão descritiva sobre exposição e toxicidade ao flúor, particularmente para identificar e descrever o possível resultado adverso e efeito tóxico ocorrido por exposição tópica e sistémica. Os dados incluídos na revisão foram sistematicamente pesquisados e coletados em páginas da web (Pubmed, B-on), publicados entre os anos 2000-2017. O flúor pode ser administrado por via sistêmica ou tópica. A fonte mais importante de ingestão de flúor é a água. A maioria dos resultados de estudos da literatura revela alguns efeitos adversos relacionados com exposição a águas fluoradas. A maioria da investigação nesta temática foi efetuada em animais, e revela resultados de toxicidade associados á ingestão de fluor. Contudo, mais estudos são necessários para avaliar resultados adversos associados á exposição ao fluor em seres humanos.
Fluoride is vastly used in the dental sphere and its efficiency as anticariogenic agent has been well established. This work aims to do a descriptive review on fluoride exposure and toxicity, particularly to identify and describe the possible adverse outcome and toxic effect occurring by topic and systemic exposure to fluoride. Data we used in our review were systematically searched and collected from web pages (PubMed, B-on) published between the years 2000-2017. Fluoride can be administrated via systemic or topical way. The most important source of fluoride ingestion is fluoridated water. Our research suggests that most of the adverse outcomes linked to fluoride is due to fluoridated water. But most of the researches have been made on animals. Even though fluoride ingestion has been linked to toxicity on animals, it needs to be proven on human. More researches need to be done on fluoride effects on human.
Fluoride is vastly used in the dental sphere and its efficiency as anticariogenic agent has been well established. This work aims to do a descriptive review on fluoride exposure and toxicity, particularly to identify and describe the possible adverse outcome and toxic effect occurring by topic and systemic exposure to fluoride. Data we used in our review were systematically searched and collected from web pages (PubMed, B-on) published between the years 2000-2017. Fluoride can be administrated via systemic or topical way. The most important source of fluoride ingestion is fluoridated water. Our research suggests that most of the adverse outcomes linked to fluoride is due to fluoridated water. But most of the researches have been made on animals. Even though fluoride ingestion has been linked to toxicity on animals, it needs to be proven on human. More researches need to be done on fluoride effects on human.
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Keywords
Toxicidade fluor Administração flúor Metabolismo flúor Eficácia flúor Resultados adversos flúor Fluoride toxicity Dental fluoride toxicity Administration of fluoride Metabolism of fluoride Fluoride efficacy Fluoride adverse effects