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Publication
Envelhecimento da pele: revisão narrativa da evolução histológica
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Advisor(s)
Abstract(s)
A pele, órgão vital, separa a homeostasia interna do meio externo, funcionando como barreira fundamental contra infeções, radiações UV, perda de água e outras agressões externas.
Pretende-se descrever as características histológicas da pele, caracterizando a função das suas populações celulares e posteriormente identificar as principais alterações que ocorrem na epiderme e na derme como resultado do envelhecimento intrínseco, cronológico ou natural, que ocorre com o passar do tempo.
Foi realizada uma revisão bibliográfica narrativa com base em artigos publicados online, nos últimos dez anos. Procedeu-se ao levantamento de artigos nas bases de dados PubMed e Science Direct. Os critérios utilizados para inclusão das publicações foram (a) presença dos descritores utilizados na busca no título ou resumo; (b) artigos publicados em língua portuguesa, francesa, espanhola ou inglesa; (c) artigos de acesso livre; (d) dissertações e teses. Os critérios de exclusão foram (a) duplicidade de artigos; (b) artigos cujo conteúdo integral não atendiam ao tema proposto; (c) artigos com textos não disponibilizados completamente.
O envelhecimento da pele envolve alterações moleculares e histológicas, com consequências no organismo. Para além de visíveis alterações fenotípicas, estéticas, com impacto negativo psicológico e social, a pele envelhecida é mais frágil, mais suscetível a desidratação e posterior maceração dos tecidos. É mais vulnerável ao desenvolvimento de lesões, infeções, feridas crónicas dermatites e doenças malignas, apresentando maior dificuldade na recuperação da sua integridade como barreira.
Uma mais ampla compreensão dos fatores envolvidos no envelhecimento da pele é fundamental para o desenvolvimentos de estratégias que possam minimizar o seu impacto nas populações celulares nela presentes e assim a longevidade deste órgão vital.
The skin, a vital organ, separates internal homeostasis from the external environment, functioning as a fundamental barrier against infections, UV radiation, water loss and other external stressors. It is intended to describe the histological characteristics of the skin, characterizing the function of its cell populations and subsequently identify the main changes that occur in the epidermis and in the dermis as a result of intrinsic, chronological or natural aging, which occurs over time. A narrative literature review was carried out based on articles published online in the last ten years. Articles were surveyed in PubMed and Science Direct databases. The criteria used for inclusion of publications were (a) presence in the title or abstract of the descriptors used in the search; (b) articles published in Portuguese, French, Spanish or English; (c) free access articles; (d) dissertations and theses. The criteria used for exclusion of publications were (a) duplication of articles; (b) articles whose full content did not meet the proposed theme; (c) articles with texts not fully available. Skin aging involves molecular and histological changes, with consequences for the body. In addition to visible phenotypic and aesthetic changes, with a negative psychological and social impact, aged skin is more fragile, more susceptible to dehydration and further maceration of the tissues. It is more vulnerable to the development of injuries, infections, chronic wounds, dermatitis and malignant diseases, presenting greater difficulty in recovering its integrity as a barrier. A broader understanding of the elements involved in skin aging is fundamental for the development of strategies that can minimize its impact on the cell populations present in the skin and thus the longevity of this vital organ.
The skin, a vital organ, separates internal homeostasis from the external environment, functioning as a fundamental barrier against infections, UV radiation, water loss and other external stressors. It is intended to describe the histological characteristics of the skin, characterizing the function of its cell populations and subsequently identify the main changes that occur in the epidermis and in the dermis as a result of intrinsic, chronological or natural aging, which occurs over time. A narrative literature review was carried out based on articles published online in the last ten years. Articles were surveyed in PubMed and Science Direct databases. The criteria used for inclusion of publications were (a) presence in the title or abstract of the descriptors used in the search; (b) articles published in Portuguese, French, Spanish or English; (c) free access articles; (d) dissertations and theses. The criteria used for exclusion of publications were (a) duplication of articles; (b) articles whose full content did not meet the proposed theme; (c) articles with texts not fully available. Skin aging involves molecular and histological changes, with consequences for the body. In addition to visible phenotypic and aesthetic changes, with a negative psychological and social impact, aged skin is more fragile, more susceptible to dehydration and further maceration of the tissues. It is more vulnerable to the development of injuries, infections, chronic wounds, dermatitis and malignant diseases, presenting greater difficulty in recovering its integrity as a barrier. A broader understanding of the elements involved in skin aging is fundamental for the development of strategies that can minimize its impact on the cell populations present in the skin and thus the longevity of this vital organ.
Description
Keywords
Pele Envelhecimento Queratinócitos Melanócitos Colagénio Fibras elásticas Fibroblastos Derme Skin Aging Keratinocytes Melanocytes Collagen Elastic fibers Fibroblast Dermis