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Concentrados autólogos de plaquetas em defeitos infra ósseos: terapêutica principal ou terapêutica coadjuvante? – Revisão narrativa
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Abstract(s)
Os biomateriais que visam regenerar os tecidos de suporte dentário são ferramentas fundamentais por um tratamento conservador. Os concentrados autólogos de plaquetas fazem parte dos biomateriais autólogos derivados do sangue do próprio pacientes, os seus potenciais de cicatrização derivam dos inúmeros fatores de crescimento secretados pelas plaquetas.
As mais recentes revisões sistemáticas lançaram luz sobre a validade destes biomateriais fisiológicos, os quais mostraram resultados encorajadores quando utilizados como material regenerativo nos defeitos infra ósseos causado pela periodontite, contudo, segundo a literatura
pesquisada, não alcançam os mesmos resultados quando adicionados a outros materiais e técnicas regenerativas. Desta forma, torna-se necessário mais estudos que visem a determinar um protocolo comum e quais os casos clínicos em que podem ser utilizados.
Com esta revisão narrativa pretende-se descrever as características dos concentrados autólogos de plaquetas e comparar a sua eficácia no tratamento principal ou coadjuvante dos defeitos infra ósseos causado pela periodontite, dando ênfase aos desfechos trazidos pela adição deles aos tratamentos gold standard.
Periodontal regenerative biomaterials are crucial elements in regenerative dentistry. Autologous platelets concentrates are biomaterials derived from patient own blood, these blood concentrates support and facilitate healing process thanks to growth factors and cytokines release after platelets activation. Most recent systematic reviews shed light on efficacy of theses physiologic biomaterials, they demonstrate good results when utilize as monotherapy in intra-bony defects treatment, therefore, when they are added to some others biomaterials or techniques, they do not achieve the same results. More studies are necessary in order to establish common protocol and indications of theses promising biomaterials. The aim of this narrative review is to describe autologous platelets concentrates’ characteristics and to compare their effectiveness in intra-bony defects regeneration, focusing on the outcomes that the combination of this material to gold standards techniques achieve.
Periodontal regenerative biomaterials are crucial elements in regenerative dentistry. Autologous platelets concentrates are biomaterials derived from patient own blood, these blood concentrates support and facilitate healing process thanks to growth factors and cytokines release after platelets activation. Most recent systematic reviews shed light on efficacy of theses physiologic biomaterials, they demonstrate good results when utilize as monotherapy in intra-bony defects treatment, therefore, when they are added to some others biomaterials or techniques, they do not achieve the same results. More studies are necessary in order to establish common protocol and indications of theses promising biomaterials. The aim of this narrative review is to describe autologous platelets concentrates’ characteristics and to compare their effectiveness in intra-bony defects regeneration, focusing on the outcomes that the combination of this material to gold standards techniques achieve.
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Keywords
Intrabony defects Autologous platelets concentrates Bone regeneration Bone grafts Platelet rich fibrin