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Proteína C reativa e doença cardiovascular
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| PPG_25877 | 1015.39 KB | Adobe PDF |
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Abstract(s)
As doenças cardiovasculares (DCVs) são a primeira causa de morte nos países desenvolvidos (≈ 50% na Europa e 32% em Portugal), logo torna-se importante a eliminação deste problema de saúde pública. Ao longo dos anos, o conhecimento na área das DCVs tem vindo a aumentar e hoje sabe-se que uma das causas mais comuns é o desenvolvimento da aterosclerose. Esta patologia não resulta apenas de uma acumulação de lípidos na parede arterial, mas também de um processo inflamatório complexo. Os biomarcadores inflamatórios constituem uma ferramenta valiosa na deteção e acompanhamento da evolução deste processo, assim como na terapêutica a implementar. A proteína C reativa (CRP), determinada por métodos de alta sensibilidade (CRP-hs), destaca-se entre os restantes biomarcadores, sendo o mais estudado. A CRP é considerada um importante marcador da reação inflamatória, não havendo grandes flutuações diurnas nem sazonais nas suas concentrações plasmáticas. Esta proteína é também indicada como um relevante mediador do processo aterosclerótico. Os dados relativos à associação entre hs-CRP e o risco cardiovascular são amplamente consistentes, embora apresentem relevância clínica incerta. O recurso à utilização destes biomarcadores permite a deteção, acompanhamento e prevenção de DCVs.
Cardiovascular diseases (CVD) are the first cause of death in developed countries (≈ 50% in Europe and 32% in Portugal), therefore it is of particular interest to reduce this public health problem. Over the years, the knowledge in the area of cardiovascular diseases has been increasing and today it is known that one of its most common causes is the development of atherosclerosis. This pathology not only results from the accumulation of lipids in the arterial wall, but also from a complex inflammatory process. Inflammatory biomarkers are a valuable tool in the detection and monetarization of the evolution of this process, as well as therapy to implement. C-reactive protein (CRP), determined by high sensitivity methods (hs-CRP), is the biomarker most studied and stands out among the others. CRP is an important marker of inflammation, and its concentration is not affected by large diurnal or seasonal variations. This protein is also indicated as an important mediator of the atherosclerotic process. Data on the association between hs-CRP and cardiovascular risk are broadly consistent, although they have uncertain clinical relevance. The use of these biomarkers allow the detection, monitoring and prevention of CVD.
Cardiovascular diseases (CVD) are the first cause of death in developed countries (≈ 50% in Europe and 32% in Portugal), therefore it is of particular interest to reduce this public health problem. Over the years, the knowledge in the area of cardiovascular diseases has been increasing and today it is known that one of its most common causes is the development of atherosclerosis. This pathology not only results from the accumulation of lipids in the arterial wall, but also from a complex inflammatory process. Inflammatory biomarkers are a valuable tool in the detection and monetarization of the evolution of this process, as well as therapy to implement. C-reactive protein (CRP), determined by high sensitivity methods (hs-CRP), is the biomarker most studied and stands out among the others. CRP is an important marker of inflammation, and its concentration is not affected by large diurnal or seasonal variations. This protein is also indicated as an important mediator of the atherosclerotic process. Data on the association between hs-CRP and cardiovascular risk are broadly consistent, although they have uncertain clinical relevance. The use of these biomarkers allow the detection, monitoring and prevention of CVD.
Description
Keywords
Doença cardiovascular Aterosclerose Processo inflamatório Biomarcadores inflamatórios Proteína C reativa Proteína C reativa de alta sensibilidade Fatores de risco Prevenção Cardiovascular disease Atherosclerosis Inflammatory process Inflammatory biomarkers C reactive protein High sensitive C reactive protein Risk factors Prevention