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Mycobacterium avium subsp paratuberculosis detection from blood of Crohn's disease patients in a portuguese hospital

2010Journal article Open access
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dc.contributor.authorMartinho, António
dc.contributor.authorCampos, Nair
dc.contributor.authorRodrigues, Pedro
dc.contributor.authorMagro, Fernando
dc.contributor.authorSarmento, Amélia
dc.date.accessioned2012-04-24T16:43:33Z
dc.date.available2012-04-24T16:43:33Z
dc.date.issued2010
dc.description.abstractMycobacterium avium subsp paratuberculosis (MAP) has been associated with Crohn’s disease (CD). We performed MAP DNA detection in the blood of controls and CD patients followed at Hospital de São João, by IS900-based nested PCR. We found that 60% (6 out of 10) of CD patients were positive for MAP DNA, against 38% (8 out of 21) of control subjects. MAP detection in CD patients will allow us to correlate MAP infection with different pathological and immunological patterns of the disease. Mycobacterium avium subsp paratuberculosis (MAP) tem vindo a ser associada com a doença de Crohn (CD). Neste trabalho realizamos a detecção por nested PCR de DNA de MAP, no sangue de controlos e de doentes com CD seguidos no Hospital de São João. Detectámos seis (em 10) pacientes positivos para DNA de MAP (60%), e sete (em 20) controlos positivos (35%). A detecção de MAP em doentes com CD permitirá estudar possíveis correlações entre a infecção por MAP e diferentes características patológicas e imunológicas da CD.por
dc.identifier.citationRevista da Faculdade de Ciências da Saúde. Porto: Edições Universidade Fernando Pessoa. ISSN 1646-0480. 7 (2010) 74-79.por
dc.identifier.issn1646-0480
dc.identifier.urihttp://hdl.handle.net/10284/2995
dc.language.isoengpor
dc.publisherEdições Universidade Fernando Pessoapor
dc.relation.ispartofseriesRevista da Faculdade de Ciências da Saúde;7 (2010)
dc.subjectMycobacterium avium subsp paratuberculosispor
dc.subjectNested PCRpor
dc.subjectCrohn’s diseasepor
dc.subjectPCRpor
dc.subjectDoença de Crohnpor
dc.titleMycobacterium avium subsp paratuberculosis detection from blood of Crohn's disease patients in a portuguese hospitalpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage79por
oaire.citation.startPage74por
person.familyNameNazareth Campos
person.familyNameMagro
person.familyNameSarmento
person.givenNameNair
person.givenNameFernando
person.givenNameAmélia
person.identifier118915
person.identifier.ciencia-idCA17-881A-868F
person.identifier.ciencia-idC616-293B-A303
person.identifier.ciencia-id1A1F-EB62-2AF9
person.identifier.orcid0000-0001-6297-4773
person.identifier.orcid0000-0003-2634-9668
person.identifier.orcid0000-0001-5137-8474
person.identifier.ridN-2547-2013
person.identifier.scopus-author-id55901273800
person.identifier.scopus-author-id7007082944
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication7b2e3d47-0650-47de-975d-77840654c958
relation.isAuthorOfPublication18933263-0f0f-49b9-9e3a-bb61719e38e8
relation.isAuthorOfPublication5593cdec-ca85-4f05-b4f2-97193accaaab
relation.isAuthorOfPublication.latestForDiscovery18933263-0f0f-49b9-9e3a-bb61719e38e8

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FCS - Número 07 (2010)