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O papel do canabidiol no tratamento da adição ao álcool e na prevenção da recidiva
| Name: | Description: | Size: | Format: | |
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| Projeto de pós-graduação_42272 | 623.57 KB | Adobe PDF |
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Abstract(s)
Com a legalização da canábis medicinal, surge um aumento na disponibilidade e exposição aos seus constituintes, em particular o canabidiol (CBD), o principal composto não psicoativo. O objetivo desta dissertação foi analisar o uso do CBD no tratamento de adições a drogas, em particular, no consumo excessivo de álcool e na recidiva, bem como o seu mecanismo de ação. Para tal, foi realizada uma revisão abrangente de estudos clínicos e pré-clínicos em modelos animais e humanos, com a finalidade de examinar os efeitos da administração de CBD nas respostas ao álcool. Para realizar esta revisão, foi efetuada uma pesquisa de artigos científicos em bases de dados como a PubMed, Science Direct, B-on e Google Académico, utilizando as seguintes palavras-chave: "Canabidiol", "Δ9-tetrahidrocanabidiol", "canábis medicinal", "adições" e "álcool". Também foi recolhida informação em websites governamentais através do motor de busca "Google". As evidências de vários estudos sugerem que o CBD pode atenuar o consumo excessivo de álcool, reduzindo o seu consumo, a motivação para consumir, a ansiedade, impulsividade e o risco de recaída, além de potencialmente proteger contra certos efeitos nocivos do álcool. O CBD demonstrou reduzir a esteatose e a fibrose relacionadas ao álcool, reduzindo a acumulação de lípidos, estimulando a autofagia, modulando a inflamação e reduzindo o stress oxidativo. A dependência de álcool parece estar associada a uma função amigdalar desregulada, e o consumo excessivo de álcool altera os níveis de endocanabinoides cerebrais. O bloqueio farmacológico da sinalização endocanabinoide leva a uma redução no desejo pelo consumo de álcool e, consequentemente, reduz o comportamento de recaída em indivíduos dependentes. Estudos em modelos animais e humanos mostram que o CBD foi bem tolerado e não interagiu com os efeitos subjetivos do álcool. Devido aos seus efeitos benéficos nesta condição, o CBD parece ser um candidato promissor no tratamento do uso do álcool (TUA), no entanto, a escassez de estudos impede quaisquer conclusões definitivas relativamente às interações CBD e álcool.
The legalization of medicinal cannabis has led to increased availability and exposure to its constituents, particularly cannabidiol (CBD), the main non-psychoactive compound. This dissertation explores the use of CBD in treating drug addictions, focusing on excessive alcohol consumption and relapse, along with its mechanism of action. To achieve this, an extensive review of clinical and preclinical studies in animal and human models was conducted to examine the effects of CBD administration on alcohol-related responses. A comprehensive search for scientific articles was carried out in databases such as PubMed, Science Direct, B-on and Google Scholar, using the following keywords: "Cannabidiol", "Δ9-tetrahydrocannabidiol", "medical cannabis", "addictions" and "alcohol". Additionally, information was gathered from government websites through the "Google" search engine. Evidence suggests that CBD can mitigate excessive alcohol consumption by reducing consumption, motivation, anxiety, impulsivity, and the risk of relapse, potentially protecting against certain harmful effects of alcohol. CBD has been shown to reduce alcohol-related steatosis and fibrosis by decreasing lipid accumulation, stimulating autophagy, modulating inflammation, and reducing oxidative stress. Alcohol dependence appears to be linked to dysregulated amygdala function, and excessive alcohol consumption alters endocannabinoid levels in the brain. Pharmacological blockade of endocannabinoid signaling leads to a reduction in the desire for alcohol consumption, consequently reducing relapse behavior in dependent individuals. Studies conducted in animal and human models show that CBD was well tolerated and did not interact with the subjective effects of alcohol. Due to its beneficial effects in treating alcohol use disorder, CBD emerges as a promising candidate in alcohol use disorder (AUD) treatment. However, the scarcity of studies prevents any definitive conclusions regarding CBD-alcohol interactions.
The legalization of medicinal cannabis has led to increased availability and exposure to its constituents, particularly cannabidiol (CBD), the main non-psychoactive compound. This dissertation explores the use of CBD in treating drug addictions, focusing on excessive alcohol consumption and relapse, along with its mechanism of action. To achieve this, an extensive review of clinical and preclinical studies in animal and human models was conducted to examine the effects of CBD administration on alcohol-related responses. A comprehensive search for scientific articles was carried out in databases such as PubMed, Science Direct, B-on and Google Scholar, using the following keywords: "Cannabidiol", "Δ9-tetrahydrocannabidiol", "medical cannabis", "addictions" and "alcohol". Additionally, information was gathered from government websites through the "Google" search engine. Evidence suggests that CBD can mitigate excessive alcohol consumption by reducing consumption, motivation, anxiety, impulsivity, and the risk of relapse, potentially protecting against certain harmful effects of alcohol. CBD has been shown to reduce alcohol-related steatosis and fibrosis by decreasing lipid accumulation, stimulating autophagy, modulating inflammation, and reducing oxidative stress. Alcohol dependence appears to be linked to dysregulated amygdala function, and excessive alcohol consumption alters endocannabinoid levels in the brain. Pharmacological blockade of endocannabinoid signaling leads to a reduction in the desire for alcohol consumption, consequently reducing relapse behavior in dependent individuals. Studies conducted in animal and human models show that CBD was well tolerated and did not interact with the subjective effects of alcohol. Due to its beneficial effects in treating alcohol use disorder, CBD emerges as a promising candidate in alcohol use disorder (AUD) treatment. However, the scarcity of studies prevents any definitive conclusions regarding CBD-alcohol interactions.
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Keywords
Canabidiol Δ9-tetrahidrocanabidiol Canábis medicinal Adições Álcool Cannabidiol Δ9-tetrahydrocannabidiol Medical cannabis Addictions Alcohol