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Publication
Second primary malignancy after curative treatment of oral squamous cell carcinoma
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| PPG_29937 | 976.15 KB | Adobe PDF |
Advisor(s)
Abstract(s)
Os carcinomas de células escamosas da cabeça e pescoço foram os sextos cancros mais comuns em Portugal em 2010. Uma detecção precoce, uma melhor estratégia terapêutica levaram a um aumento da sobrevivência e da qualidade de vida dos doentes. No entanto, o risco de desenvolver um segundo cancro primário permanece elevado nesta população, constituindo um importante factor de morbilidade. Aproximadamente um terço das mortes dos carcinomas da cabeça e pescoço são imputáveis aos segundos primários cancros.
Um segundo cancro primário apesar de poder ser considerado uma recaída, é diferente
de uma recorrência tumoral, pelo facto de não se originar a partir do tumor primário,
apresentando um processo carcinogénico distinto que origina um novo tumor. A sua
detecção precoce revela-se um factor fundamental para aumentar as hipóteses de um
tratamento com intuito curativo. Para tal, é fundamental um melhor conhecimento dos
mecanismos que levam ao aparecimento destes segundos tumores, quais as localizações
mais frequentes e qual a probabilidade e tempo necessário para ocorrerem.
O objectivo deste estudo foi comparar os diversos relatos na literatura científica, sobre a realidade da distribuição dos segundos cancros primários e a sua frequência após um tratamento inicial para um carcinoma da cabeça e pescoço. O conhecimento desta realidade será de grande importância para o médico dentista, permitindo uma adequada gestão dos doentes com cancro oral.
A revisão bibliográfica foi realizada a partir das bases PubMed, B-on, Cancer Network, Science Direct e repositório institucional da Universidade Fernando Pessoa.
Head and Neck squamous cell carcinoma (HNSCC) was the sixth most common cancer in Portugal in 2010. Earlier detection, better therapeutic management has led to an increase survival in patients' lifespan and quality of life. However, the risk of developing second primary malignancy remains elevated in this population and is still an important morbidity factor. Approximately one-third of HNSCC deaths are attributable to second primary cancers. A second primary cancer may be considered a relapse, but differs from tumour recurrence, by the fact that it doesn’t originate from the primary tumor and presents its own carcinogenic process that will generate a new tumor. Early detection is a fundamental factor to increase the hypotheses of a treatment with a curative objective. For these reasons it is fundamental to have a better knowledge of the appearance mechanisms of secondary tumours, their most frequent locations and how likely and how long they can occur. The purpose of this study is to compare the different relations in the scientific literature and articles, to analyse the reality of the distribution of second primary cancers and their frequency after initial treatment for a head and neck carcinoma. Knowledge of this reality will be important for the dentist, allowing adequate management of patients with oral cancer. A bibliographic review was carried from PubMed, B-on, Cancer Network, Science Direct and the Fernando Pessoa University institutional repository.
Head and Neck squamous cell carcinoma (HNSCC) was the sixth most common cancer in Portugal in 2010. Earlier detection, better therapeutic management has led to an increase survival in patients' lifespan and quality of life. However, the risk of developing second primary malignancy remains elevated in this population and is still an important morbidity factor. Approximately one-third of HNSCC deaths are attributable to second primary cancers. A second primary cancer may be considered a relapse, but differs from tumour recurrence, by the fact that it doesn’t originate from the primary tumor and presents its own carcinogenic process that will generate a new tumor. Early detection is a fundamental factor to increase the hypotheses of a treatment with a curative objective. For these reasons it is fundamental to have a better knowledge of the appearance mechanisms of secondary tumours, their most frequent locations and how likely and how long they can occur. The purpose of this study is to compare the different relations in the scientific literature and articles, to analyse the reality of the distribution of second primary cancers and their frequency after initial treatment for a head and neck carcinoma. Knowledge of this reality will be important for the dentist, allowing adequate management of patients with oral cancer. A bibliographic review was carried from PubMed, B-on, Cancer Network, Science Direct and the Fernando Pessoa University institutional repository.
Description
Keywords
Segundo cancro primário Cabeça e pescoço Carcinoma de células escamosas Cancro oral Second primary malignancy Head and neck Squamous cell carcinoma Oral cancer