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Association of rs324420 (C385A) polymorphism with high-level performance in volleyball players

2023-05-26Artigo científico Acesso restrito
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dc.contributor.authorSilva, Hugo-Henrique
dc.contributor.authorTavares, Valéria
dc.contributor.authorSilva, Maria Raquel
dc.contributor.authorNeto, Beatriz Vieira
dc.contributor.authorCerqueira, Fátima
dc.contributor.authorMedeiros, Rui
dc.date.accessioned2026-04-20T10:41:09Z
dc.date.available2026-04-20T10:41:09Z
dc.date.issued2023-05-26
dc.description.abstractGenetic variants are recognized to affect athletic performance, partially by modulating competition-facilitating behavior. In this study, the role of three genetic variants previously linked to athlete status was investigated among elite volleyball players. A total of 228 players (26.7 ± 8.1 years old) participating in the Portuguese championship and with multiple medalists in national and international competitions were evaluated in terms of anthropometrics, training regime, sports experience, and a history of sports lesions. SNP genotyping was conducted by means of TaqMan Allelic Discrimination Methodology. Volleyball players showed significantly different anthropometric indicators and training habits according to sex ( < 0.05). The A allele of the genetic variant () rs324420 (C385A) was shown to be significantly associated with superior athletic achievements under a dominant genetic model (AA/AC vs. CC, odds ratio (OR) = 1.70; 95% Cl, 0.93-3.13; = 0.026; < 0.001 after Bootstrap), which was corroborated by a multivariable analysis (AA/AC vs. CC adjusted OR = 2.00; 95% Cl, 1.04-3.82; = 0.037). Age and hand length were also found to be independently associated with high-level performance ( < 0.05). Our results confirm the role of in athletic performance. More investigation into this polymorphism's potential impact on stress coping, pain, and inflammation regulation in sport, particularly in the scope of lesions prevention and treatment, is required.eng
dc.identifier.citationSilva, H.-H., Tavares, V., Silva, M.-R. G., Neto, B. V., Cerqueira, F., & Medeiros, R. (2023). Association of FAAH rs324420 (C385A) polymorphism with high-level performance in volleyball players. Genes, 14(6), 1164. https://doi.org/10.3390/genes14061164
dc.identifier.doihttps://doi.org/10.3390/genes14061164
dc.identifier.issn2073-4425
dc.identifier.other37372343
dc.identifier.urihttp://hdl.handle.net/10284/15356
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relation.hasversionhttps://www.mdpi.com/2073-4425/14/6/1164
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectFAAH
dc.subjectHigh-level performance
dc.subjectVolleyball
dc.subjectGene
dc.subjectPolymorphism
dc.titleAssociation of rs324420 (C385A) polymorphism with high-level performance in volleyball playerseng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue6
oaire.citation.startPage1164
oaire.citation.titleGenes
oaire.citation.volume14
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameSilva
person.familyNameTavares
person.familyNameSilva
person.familyNameCerqueira
person.familyNameMedeiros
person.givenNameHugo-Henrique
person.givenNameValéria
person.givenNameMaria Raquel
person.givenNameFátima
person.givenNameRui
person.identifier812695
person.identifier37604
person.identifier.ciencia-id2518-6117-FB25
person.identifier.ciencia-idCF14-52ED-5DA0
person.identifier.ciencia-idC51F-5DBE-9C51
person.identifier.orcid0000-0002-2026-6960
person.identifier.orcid0000-0003-3680-7757
person.identifier.orcid0000-0001-8170-3119
person.identifier.orcid0000-0003-4513-4654
person.identifier.orcid0000-0003-3010-8373
person.identifier.ridM-7557-2013
person.identifier.ridC-7938-2009
person.identifier.scopus-author-id57189251197
person.identifier.scopus-author-id56924197900
person.identifier.scopus-author-id6603346911
person.identifier.scopus-author-id7006241641
relation.isAuthorOfPublicationbbebbedb-7c5f-4ee3-8223-e37a5612decc
relation.isAuthorOfPublication944a41f5-0d57-4860-b429-bb73d0109e9c
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