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Causas genéticas de má oclusão
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| PPG_33740 | 231.64 KB | Adobe PDF |
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Abstract(s)
Os casos de má oclusão afetam indivíduos em todo o mundo, resultando em comprometimento da função e estética.
Compreendendo os fatores etiológicos que contribuem para a variação na morfologia dentofacial associado a más oclusões é a chave para desenvolver novas abordagens de tratamento.
Os avanços na fenotipagem dentofacial, que é a caracterização abrangente da variação de tecidos moles e duros no complexo craniofacial, juntamente com a aquisição de dados genómicos em larga escala, começaram a desvendar os mecanismos genéticos subjacentes à variação facial. O conhecimento sobre a genética da má oclusão humana é limitado, embora os resultados alcançados até ao momento sejam encorajadores, com oportunidades promissoras para pesquisas futuras.
Este trabalho teve como objetivo fazer uma revisão narrativa bibliográfica das causas genéticas da má oclusão. A pesquisa foi realizada nas plataformas Pubmed, Medline, Scielo e Google academic e foram utilizadas as palavras-chave “genética” e “má oclusão”.
Este trabalho resume as variações dentofaciais mais comuns associadas a más oclusões e faz uma revisão do conhecimento atual do papel dos genes no seu desenvolvimento.
Por fim, este trabalho descreverá maneiras de avançar na pesquisa de más oclusões, seguindo exemplos dos campos em expansão da medicina genómica e fenómica, que visam melhores resultados para os pacientes.
Malocclusions affect individuals worldwide, resulting in compromised function and aesthetics. Understanding the etiological factors contributing to the variation in dentofacial morphology associated with malocclusions is the key to develop novel treatment approaches. Advances in dentofacial phenotyping, which is the comprehensive characterization of hard and soft tissue variation in the craniofacial complex, together with the acquisition of large-scale genomic data have started to unravel genetic mechanisms underlying facial variation. Knowledge on the genetics of human malocclusion is limited even though results attained thus far are encouraging, with promising opportunities for future research. This work aimed to make a bibliographic narrative review of the genetic causes of malocclusion. Research was carried out in Pubmed, Medline, Scielo and Google academic platforms and the keywords “genetics” and “malocclusion” were used. This work summarizes the most common dentofacial variations associated with malocclusions and reviews the current knowledge of the roles of genes in the development of malocclusions. Lastly, this work will describe ways to advance malocclusion research, following examples from the expanding fields of phenomics and genomic medicine, which aim to better patient outcomes.
Malocclusions affect individuals worldwide, resulting in compromised function and aesthetics. Understanding the etiological factors contributing to the variation in dentofacial morphology associated with malocclusions is the key to develop novel treatment approaches. Advances in dentofacial phenotyping, which is the comprehensive characterization of hard and soft tissue variation in the craniofacial complex, together with the acquisition of large-scale genomic data have started to unravel genetic mechanisms underlying facial variation. Knowledge on the genetics of human malocclusion is limited even though results attained thus far are encouraging, with promising opportunities for future research. This work aimed to make a bibliographic narrative review of the genetic causes of malocclusion. Research was carried out in Pubmed, Medline, Scielo and Google academic platforms and the keywords “genetics” and “malocclusion” were used. This work summarizes the most common dentofacial variations associated with malocclusions and reviews the current knowledge of the roles of genes in the development of malocclusions. Lastly, this work will describe ways to advance malocclusion research, following examples from the expanding fields of phenomics and genomic medicine, which aim to better patient outcomes.
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Keywords
Má oclusão Genética Genes Fenótipo Genótipo Hereditariedade Tratamento Malocclusion Genetics Genes Phenotype Genotype Heredity Treatment