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Formulations based on Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) for cutaneous use: a review

2018Journal article Restricted access
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dc.contributor.authorGarcês, A.
dc.contributor.authorAmaral, M.H.
dc.contributor.authorSousa Lobo, J.M.
dc.contributor.authorSilva, Ana Catarina
dc.date.accessioned2021-04-27T12:49:06Z
dc.date.available2021-04-27T12:49:06Z
dc.date.issued2018
dc.description.abstractCutaneous use of lipid nanoparticles (solid lipid nanoparticles, SLN and nanostructured lipid carriers, NLC) has been showing promising results. These systems consist of low viscosity aqueous dispersions, being usually employed by means of semi-solid formulations with adequate consistency for skin application. This review addresses the cutaneous use of lipid nanoparticles for therapeutic and cosmetic applications. Initially, general information related to pharmaceutical semi-solid formulations is presented. Afterwards, the effects of SLN and NLC on the skin, and technological aspects related to semi-solid systems based on SLN or NLC are described. Finally, the most relevant studies related to the formulations based on SLN and NLC, for cosmetic and therapeutic applications, are reported. Notwithstanding the cutaneous use of SLN and NLC has been proposed for both local and transdermal delivery, the reported studies show promising results only for local application. In this sense, more research is required to better understanding the interaction mechanisms of lipid nanoparticles with skin lipids. Furthermore, the development of standard methods for skin experiments with nanoparticles is necessary.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.ejps.2017.11.023pt_PT
dc.identifier.issn0928-0987
dc.identifier.urihttp://hdl.handle.net/10284/9803
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectCutaneous usept_PT
dc.subjectNanostructured lipid carrierspt_PT
dc.subjectSkin formulationspt_PT
dc.subjectSolid lipid nanoparticlespt_PT
dc.titleFormulations based on Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) for cutaneous use: a reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage167pt_PT
oaire.citation.startPage159pt_PT
oaire.citation.titleEuropean Journal of Pharmaceutical Sciencespt_PT
oaire.citation.volume112pt_PT
person.familyNameSilva
person.givenNameAna Catarina
person.identifier953153
person.identifier.ciencia-id5C1D-ED22-0D64
person.identifier.orcid0000-0001-6923-0232
person.identifier.ridF-1875-2017
person.identifier.scopus-author-id57028697500
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication67e7f707-32ec-444a-a20d-a17f8e6e7c21
relation.isAuthorOfPublication.latestForDiscovery67e7f707-32ec-444a-a20d-a17f8e6e7c21

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