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Publication
Biofilmes e antimicrobianos
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| PPG_26085 | 1.57 MB | Adobe PDF |
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Advisor(s)
Abstract(s)
A formação de biofilmes é atualmente reconhecido como um dos fatores mais relevantes
nas infeções crónicas. Estes são comunidades bacterianas agregadas, envolvidas numa
matriz polimérica extracelular, com capacidades de adesão a superfícies bióticas e
abióticas. A formação de um biofilme ocorre geralmente em várias etapas consecutivas.
As características importantes das infecções crónicas baseadas em biofilmes são a extrema
resistência e tolerância aos antibióticos e a muitos outros agentes antimicrobianos
convencionais bem como a capacidade extrema para evitar as defesas do hospedeiro. Deste
modo, é urgente as pesquisas e os avanços da ciência bem como da tecnologia nesta área
com o intuito de adquirir métodos mais rápidos para o diagnóstico dos biofilmes e
consequente eficácia na terapêutica.
O tratamento de infeções por biofilmes é atualmente um desafio difícil e complicado para
microbiologistas, clínicos, médicos e enfermeiros. Deste modo, é relevante conceber um
algoritmo de atuação para controlo dos biofilmes no sentido de auxiliar os profissionais de
saúde, e que permita também otimizar a identificação de biofilmes e terapêutica dos
mesmos na prática clínica.
Como se explica a existência de biofilmes? Qual a necessidade de distinguir o paradigma
plantónico do paradigma séssil? O paradigma séssil deverá ter mais relevância na clínica?
Como combater este grave problema de saúde pública?
Nowadays the formation of biofilms is recognized as one of the most relevant factors in chronic infections. Biofilms are aggregated bacterial communities, envolved in a polymeric extracellular matrix, with capability to adhere to abiotic and biotic surfaces. The formation of a biofilm, generally occurs in various sequential steps. The important characteristics of chronic infections based in biofilms are the extreme resistance and tolerance to antibiotics and many other conventional antimicrobial agents, as well as the extreme capability to evade the host's immune system. In this manner, the researchs and scientific advancements as well as technological improvements are urgent, in order to acquiry faster methods for biofilm diagnosis and treatment efficacy. Currently, the treatment of biofilm infections is difficult and complicated for microbiologists, doctors, practitioners and nurses. Therefore, it's relevant to conceive an algorithm for biofilm control, to auxiliate health care assistants, and to also permit biofilm identification and treatment in clinical practice. How do we explain biofilm existence? What's the necessity to differentiatite the sessile and platonic paradigms? Is the sessile paradigm more relevant clinically? How to overcome this serious public health problem?
Nowadays the formation of biofilms is recognized as one of the most relevant factors in chronic infections. Biofilms are aggregated bacterial communities, envolved in a polymeric extracellular matrix, with capability to adhere to abiotic and biotic surfaces. The formation of a biofilm, generally occurs in various sequential steps. The important characteristics of chronic infections based in biofilms are the extreme resistance and tolerance to antibiotics and many other conventional antimicrobial agents, as well as the extreme capability to evade the host's immune system. In this manner, the researchs and scientific advancements as well as technological improvements are urgent, in order to acquiry faster methods for biofilm diagnosis and treatment efficacy. Currently, the treatment of biofilm infections is difficult and complicated for microbiologists, doctors, practitioners and nurses. Therefore, it's relevant to conceive an algorithm for biofilm control, to auxiliate health care assistants, and to also permit biofilm identification and treatment in clinical practice. How do we explain biofilm existence? What's the necessity to differentiatite the sessile and platonic paradigms? Is the sessile paradigm more relevant clinically? How to overcome this serious public health problem?
Description
Keywords
Biofilmes Resistência aos antimicobianos Microrganismos Antibiofilme Diagnóstico do biofilme Tratamento dos biofilmes Biofilm Antimicrobial resistance Microorganisms Antibiofilm Biofilm diagnosis Biofilm treatment