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Relação entre a microbiota intestinal e o cérebro
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| Projeto de pós-graduação_42274 | 664.38 KB | Adobe PDF |
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Abstract(s)
A microbiota é constituída por um conjunto complexo de microrganismos que habitam num ambiente específico, sendo a microbiota intestinal a que apresenta uma densidade celular mais elevada.
O eixo microbiota-intestino-cérebro é um eixo neuroendócrino diligente que apresenta ligações entre o sistema nervoso central, o trato gastrointestinal e o sistema nervoso entérico. Este controla e anexa funções intestinais, unindo os centros cognitivos do cérebro aos mecanismos e funções intestinais periféricas.
A comunicação/interação entre o intestino, a microbiota e o cérebro é realizada por um total de quatro vias de comunicação: a endócrina, a imunológica, a metabólica e a neuronal, que se relacionam entre si de maneira diligente.
Modificações neste eixo podem levar a problemas de desenvolvimento e crescimento, compreendendo o desenvolvimento do sistema nervoso central, que estão relacionados com o aparecimento de inúmeras doenças, tais como doença de Alzheimer e doença de Parkinson.
Distúrbios gastrointestinais estão diretamente associados a estas doenças, pelo que tratamentos com prebióticos e probióticos estão a ser estudados para uma tardia evolução, alívio dos sintomas e quiçá para a cura destas doenças.
Este estudo tem como objetivo principal, através de uma revisão narrativa atual, abordar a ligação microbiota intestinal-cérebro, reunindo fatos científicos sobre a importância da microbiota intestinal, sobre o eixo microbiota-intestino-cérebro e de que maneira se pode realizar intervenções terapêuticas, assim como o impacto destas em doenças neurodegenerativas.
The microbiota is made up of a complex set of microorganisms that inhabit a specific environment, with the intestinal microbiota having the highest cell density. The microbiota-gut-brain axis is a diligent neuroendocrine axis that features links between the central nervous system, the gastrointestinal tract, and the enteric nervous system. This controls and attaches intestinal functions, linking the brain's cognitive centers to peripheral intestinal mechanisms and functions. The communication/interaction between the intestine, the microbiota and the brain is carried out by a total of four communication pathways: endocrine, immunological, metabolic, and neuronal, which are diligently related to each other. Modifications in this axis can lead to development and growth problems, including the development of the central nervous system, which are related to the onset of numerous diseases, such as Alzheimer's disease and Parkinson's disease. Gastrointestinal disorders are directly associated with these diseases, so treatments with prebiotics and probiotics are being studied for a later evolution, relief of symptoms and perhaps for the cure of these diseases. This study aims, through a current narrative review, to address the intestinal microbiota-brain connection, gathering emerging facts about the intestinal microbiota, about the microbiota-gut-brain axis and how therapeutic interventions can be carried out and their impact on neurodegenerative diseases.
The microbiota is made up of a complex set of microorganisms that inhabit a specific environment, with the intestinal microbiota having the highest cell density. The microbiota-gut-brain axis is a diligent neuroendocrine axis that features links between the central nervous system, the gastrointestinal tract, and the enteric nervous system. This controls and attaches intestinal functions, linking the brain's cognitive centers to peripheral intestinal mechanisms and functions. The communication/interaction between the intestine, the microbiota and the brain is carried out by a total of four communication pathways: endocrine, immunological, metabolic, and neuronal, which are diligently related to each other. Modifications in this axis can lead to development and growth problems, including the development of the central nervous system, which are related to the onset of numerous diseases, such as Alzheimer's disease and Parkinson's disease. Gastrointestinal disorders are directly associated with these diseases, so treatments with prebiotics and probiotics are being studied for a later evolution, relief of symptoms and perhaps for the cure of these diseases. This study aims, through a current narrative review, to address the intestinal microbiota-brain connection, gathering emerging facts about the intestinal microbiota, about the microbiota-gut-brain axis and how therapeutic interventions can be carried out and their impact on neurodegenerative diseases.
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Keywords
Microbiota intestinal Cérebro Dieta Probióticos Prébióticos Gut microbiota Brain Diet Probiotics Prebiotics