Loading...
Publication
Dentinogénese imperfeita: breve revisão
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 130.95 KB | Adobe PDF |
Advisor(s)
Abstract(s)
A dentinogénese é um processo altamente controlado que resulta na transformação
paulatina de um tecido não mineralizado numa matriz mineralizada. Interferências
na fase de mineralização podem acarretar alterações dentinárias que, dependendo do
grau de severidade, têm impacto na dentição decídua ou permanente, do seu portador.
A Dentinogénese Imperfeita é uma desordem hereditária com carácter autossómico
dominante. Entender as bases moleculares que levam ao seu estabelecimento, assim
como os seus sinais clínicos e radiográficos, é essencial para uma adequada abordagem do
paciente afectado. Assim, esta revisão de literatura tem como objectivo principal abordar
os aspectos genéticos que sublinham a sua ocorrência, como também, evidenciar as mais
prevalentes descobertas clínicas e radiográficas dos seus portadores. No entanto, estudos
prospectivos são necessários para que sejam elucidadas todas as peculiaridades desta
dramática condição dentária.
Dentinogenesis is a highly controlled process that results in the encompassed mineralization of the predentin into a mineralized matrix. Any interference during the mineralization phase may affect the dentin final structure, which depending on the severity of the disturbance involved, may be detected in both dentitions, deciduous and permanent. Dentinogenesis Imperfecta (DI) represents one of those abnormalities inherited in a dominant autosomic pattern. To understand the molecular basis of this disorder, as well as, its clinical and radiographic evidences, it is essential to make an appropriate diagnosis and ulterior treatment. The main goal of this literature review is to highlight the genetic aspects that underline its establishment and to report the most prevalent clinical and radiographic clues present in the patient with DI. Further studies, for certain, are extremely required to finally elucidate the outlines of this dramatic dental condition.
Dentinogenesis is a highly controlled process that results in the encompassed mineralization of the predentin into a mineralized matrix. Any interference during the mineralization phase may affect the dentin final structure, which depending on the severity of the disturbance involved, may be detected in both dentitions, deciduous and permanent. Dentinogenesis Imperfecta (DI) represents one of those abnormalities inherited in a dominant autosomic pattern. To understand the molecular basis of this disorder, as well as, its clinical and radiographic evidences, it is essential to make an appropriate diagnosis and ulterior treatment. The main goal of this literature review is to highlight the genetic aspects that underline its establishment and to report the most prevalent clinical and radiographic clues present in the patient with DI. Further studies, for certain, are extremely required to finally elucidate the outlines of this dramatic dental condition.
Description
Keywords
Dentinogénese Imperfeita Sialofosfoproteína Dentinária (DSPP) Dentina Opalescente Dentinogenesis Imperfect Dentin Sialophosprotein (DSPP) Hereditary Opalescent Dentin
Citation
Publisher
Elsevier España