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Solid lipid nanoparticles (SLN) - based hydrogels as potential carriers for oral transmucosal delivery of Risperidone: preparation and characterization studies

2012Journal article Restricted access
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dc.contributor.authorSilva, Ana Catarina
dc.contributor.authorAmaral, M.H.
dc.contributor.authorGonzález-Mira, E.
dc.contributor.authorSantos, D.
dc.contributor.authorFerreira, D.
dc.date.accessioned2021-04-30T11:30:17Z
dc.date.available2021-04-30T11:30:17Z
dc.date.issued2012
dc.description.abstractTwo different solid lipid nanoparticles (SLN)-based hydrogels (HGs) formulations were developed as potential mucoadhesive systems for risperidone (RISP) oral transmucosal delivery. The suitability of the prepared semi-solid formulations for application on oral mucosa was assessed by means of rheological and textural analysis, during 30 days. Plastic flows with thixotropy and high adhesiveness were obtained for all the tested systems, which predict their success for the oral transmucosal application proposed. The SLN remained within the colloidal range after HGs preparation. However, after 30 days of storage, a particle size increase was detected in one type of the HGs formulations. In vitro drug release studies revealed a more pronounced RISP release after SLN hydrogel entrapment, when compared to the dispersions alone. In addition, a pH-dependent release was observed as well. The predicted in vivo RISP release mechanism was Fickian diffusion alone or combined with erosion.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.colsurfb.2012.01.014pt_PT
dc.identifier.issn0927-7765
dc.identifier.urihttp://hdl.handle.net/10284/9842
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectOral mucoadhesive systemspt_PT
dc.subjectTransmucosal deliverypt_PT
dc.subjectSolid lipid nanoparticlespt_PT
dc.subjectRisperidonept_PT
dc.subjectHydrogelspt_PT
dc.subjectRheologypt_PT
dc.subjectTexturept_PT
dc.subjectKinetic modelspt_PT
dc.titleSolid lipid nanoparticles (SLN) - based hydrogels as potential carriers for oral transmucosal delivery of Risperidone: preparation and characterization studiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage248pt_PT
oaire.citation.startPage241pt_PT
oaire.citation.titleColloids and Surfaces B: Biointerfacespt_PT
oaire.citation.volume93pt_PT
person.familyNameSilva
person.givenNameAna Catarina
person.identifier953153
person.identifier.ciencia-id5C1D-ED22-0D64
person.identifier.orcid0000-0001-6923-0232
person.identifier.ridF-1875-2017
person.identifier.scopus-author-id57028697500
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication67e7f707-32ec-444a-a20d-a17f8e6e7c21
relation.isAuthorOfPublication.latestForDiscovery67e7f707-32ec-444a-a20d-a17f8e6e7c21

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