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Long-term predictors for psychological outcome of pre-symptomatic testing for late-onset neurological diseases

2018Journal article Restricted access
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dc.contributor.authorLêdo, Susana
dc.contributor.authorRamires, Ana
dc.contributor.authorLeite, Ângela
dc.contributor.authorDinis, Maria Alzira Pimenta
dc.contributor.authorSequeiros, Jorge
dc.date.accessioned2019-09-16T08:47:05Z
dc.date.available2019-09-16T08:47:05Z
dc.date.issued2018
dc.descriptionhttp://sherpa.ac.uk/romeo/issn/1769-7212/pt_PT
dc.description.abstractThis longitudinal study aimed at determining predicting variables for middle and long-term psychological disturbance due pre-symptomatic testing (PST) for two late-onset neurological diseases, Huntington disease (HD) and TTR (transthyretin protein) familial amyloid polyneuropathy (FAP) Val30Met (now classified as Val50Met). 196 clinical records of persons who performed PST at least three years ago and answered to the two stages of evaluation (before PST and least 3 years after disclosure of results) were analysed. For this purpose, regression analysis was performed, showing that the Positive Symptom Distress Index (PSDI), psychoticism, somatization and paranoid ideation dimensions assume predictive value in the middle and long-term impact for total anxiety and PSDI. The result of PST was not a relevant predictor. The application of an evaluation instrument of various psychopathological dimensions played a fundamental role in the detection of clinical situations that may arise several years later after PST. Attention should be paid to providing psychological support to persons at-risk who, at the pre-test phase, present some psychopathology indices before pursuing with genetic testing.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAPA: Lêdo, S., Ramires, A., Leite, Â., Dinis, M. A. P., & Sequeiros, J. (2018). Long-term predictors for psychological outcome of pre-symptomatic testing for late-onset neurological diseases. European Journal of Medical Genetics, 61(10), 575-580. doi:10.1016/j.ejmg.2018.03.010pt_PT
dc.identifier.doi10.1016/j.ejmg.2018.03.010pt_PT
dc.identifier.issn1878-0849
dc.identifier.urihttp://hdl.handle.net/10284/7906
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1769721217306341pt_PT
dc.subjectAdultpt_PT
dc.subjectAgedpt_PT
dc.subjectAmyloid Neuropathies, Familialpt_PT
dc.subjectAnxietypt_PT
dc.subjectAsymptomatic Diseasespt_PT
dc.subjectFactitious Disorderspt_PT
dc.subjectFemalept_PT
dc.subjectGenetic Counselingpt_PT
dc.subjectHumanspt_PT
dc.subjectHuntington Diseasept_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectGenetic Testingpt_PT
dc.titleLong-term predictors for psychological outcome of pre-symptomatic testing for late-onset neurological diseasespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage580pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage575pt_PT
oaire.citation.titleEuropean Journal of Medical Geneticspt_PT
oaire.citation.volume61pt_PT
person.familyNameLêdo
person.familyNameDinis
person.givenNameSusana
person.givenNameMaria Alzira Pimenta
person.identifier493603
person.identifier.ciencia-id4710-147D-FDAF
person.identifier.orcid0000-0003-3083-3129
person.identifier.orcid0000-0002-2198-6740
person.identifier.ridF-3309-2011
person.identifier.scopus-author-id55539804000
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationf114f5ce-d79b-44be-96b4-2ab1bf364d28
relation.isAuthorOfPublication1e85592a-e8e2-4aea-bd8e-1007c94388c0
relation.isAuthorOfPublication.latestForDiscovery1e85592a-e8e2-4aea-bd8e-1007c94388c0

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