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Tratamento da doença de Alzheimer: na atualidade e no futuro
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| PPG_33877 | 541.15 KB | Adobe PDF |
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Abstract(s)
A doença de Alzheimer representa uma das principais causas de morbilidade a nível
mundial. É o tipo de demência com maior prevalência globalmente, cuja incidência tem
aumentado devido ao envelhecimento populacional.
Apesar dos avanços tecnológicos no diagnóstico e da constante investigação nesta área,
a procura de um tratamento curativo constitui um dos maiores desafios da atualidade, na
área da saúde. As estratégias atuais para o tratamento da doença de Alzheimer têm como
principal alvo a sintomatologia, retardando apenas o desenvolvimento desta patologia.
Assim, tendo em conta esta limitações, várias equipas de investigação reúnem esforços
na busca de terapêuticas modificadoras da doença que atuem nos principais processos
fisiopatológicos.
A presente dissertação tem como objetivo realizar uma revisão bibliográfica
relativamente ao tratamento atual na doença de Alzheimer e das perspetivas futuras,
realçando os novos compostos em estudo, baseados na investigação diferencial que surgiu
nos últimos anos e que têm como objetivo ultrapassar as limitações atuais e suprir a
necessidade de novas terapêuticas modificadoras da doença.
Alzheimer's disease represents one of the leading causes of morbidity worldwide. It’s the type of dementia with the biggest prevalence globally, and the incidence has increased due to the aging population. Despite technological advances in diagnosis and constant research in this area, the search for a curative treatment is one of the biggest challenges in the health area today. Current strategies for the treatment of Alzheimer's disease have as their main target symptomatology, delaying only the development of this pathology. Thus, taking into account these limitations, several research teams join forces in the search for diseasemodifying therapies that act in the main pathophysiological processes. The present dissertation aims to carry out a bibliographic review in relation to the current treatment in Alzheimer's disease and future perspectives, highlighting the new compounds under study, based on the differential research that has emerged in recent years and which aim to overcome current limitations and supply the need for new diseasemodifying therapies.
Alzheimer's disease represents one of the leading causes of morbidity worldwide. It’s the type of dementia with the biggest prevalence globally, and the incidence has increased due to the aging population. Despite technological advances in diagnosis and constant research in this area, the search for a curative treatment is one of the biggest challenges in the health area today. Current strategies for the treatment of Alzheimer's disease have as their main target symptomatology, delaying only the development of this pathology. Thus, taking into account these limitations, several research teams join forces in the search for diseasemodifying therapies that act in the main pathophysiological processes. The present dissertation aims to carry out a bibliographic review in relation to the current treatment in Alzheimer's disease and future perspectives, highlighting the new compounds under study, based on the differential research that has emerged in recent years and which aim to overcome current limitations and supply the need for new diseasemodifying therapies.
Description
Keywords
Doença de Alzheimer Tratamento da doença de Alzheimer Demência Amiloide β Proteína Tau Terapêuticas modificadoras da doença de Alzheimer Alzheimer’s disease Alzheimer’s disease treatment Dementia β-amyloid Tau protein Disease modifying therapies