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Deficiência de vitamina D e a pandemia por COVID-19
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Abstract(s)
Ao longo dos últimos anos, a vitamina D tem sido muito estudada na influência no sistema imunitário, cancro, doenças respiratórias, infeções, entre outras, sendo que a sua deficiência tem sido associada ao aumento do risco de infeções do trato respiratório. A pandemia por COVID-19 tem tido um impacto gigante a nível mundial apresentando uma taxa de mortalidade elevada devido maioritariamente a síndromes respiratórios agudos severos e, por isso, tem estado também no foco de vários investigadores, nomeadamente a relação entre a vitamina D e a patogenicidade da COVID-19, já que a deficiência em vitamina D tem sido associada a casos mais severos da doença. Este trabalho tem como objetivo perceber o impacto da deficiência em vitamina D na pandemia por COVID-19. Tratou-se de um estudo de revisão da literatura nos últimos 6 anos, tendo-se recorrido à Pubmed, Scielo e Science Direct onde foram utilizadas as seguintes palavras-chave: “vitamin D”, “vitamin D deficiency”, “COVID-19”, “SARS-CoV-2”, “elderly”, “children”, “pregnancy”, “athletes”. Obtiveram-se 1684 publicações que foram posteriormente analisadas e selecionadas consoante os critérios de inclusão/exclusão. De entre os resultados obtidos na pesquisa, uma grande parte dos autores referem uma grande prevalência de deficiência em vitamina D por todo o mundo em geral, associando-a a várias patologias, inclusive à COVID-19. Por ser um assunto tão recente, e apesar de existirem já muitos estudos sobre o assunto, é possível verificar que ainda há muito por investigar quanto ao papel da vitamina D quer na COVID-19, quer noutro tipo de patologias, uma vez que os resultados se tornam controversos.
The aim of this work is to understand the impact of vitamin D deficiency in the COVID-19 pandemic. Over the last few years vitamin D has been extensively studied in the immune system importance, cancer, respiratory disease, infection, among others, and its deficiency has been associated with increased risk of respiratory infections. COVID-19 pandemic has been a huge impact worldwide presenting a high mortality rate mainly because of severe acute respiratory syndrome and thus has been on focus of some investigators, namely the relation between vitamin D and COVID-19 pathogenicity, as the vitamin D deficiency has been associated with severe illness cases. This is the main goal of this paper. This has been a literature review study in the last 6 years using Pubmed, Scielo and Science Direct with the following keywords: “vitamin D”, “vitamin D deficiency”, “COVID-19”, “SARS-CoV-2”, “elderly”, “children”, “pregnancy”, “athletes”. The result was 1684 publications which were later analyzed and selected depending on the inclusion/exclusion criteria. Among the obtained results in the research, most of the authors report a high prevalence of vitamin D deficiency worldwide and associate them to various pathologies, including COVID-19. Because is a fresh subject and although there are many reviews about this subject, it´s possible to see that there’s still a lot to investigate about vitamin D function whether in COVID-19 disease, whether in other pathologies, as the results sometimes may be inconsistent.
The aim of this work is to understand the impact of vitamin D deficiency in the COVID-19 pandemic. Over the last few years vitamin D has been extensively studied in the immune system importance, cancer, respiratory disease, infection, among others, and its deficiency has been associated with increased risk of respiratory infections. COVID-19 pandemic has been a huge impact worldwide presenting a high mortality rate mainly because of severe acute respiratory syndrome and thus has been on focus of some investigators, namely the relation between vitamin D and COVID-19 pathogenicity, as the vitamin D deficiency has been associated with severe illness cases. This is the main goal of this paper. This has been a literature review study in the last 6 years using Pubmed, Scielo and Science Direct with the following keywords: “vitamin D”, “vitamin D deficiency”, “COVID-19”, “SARS-CoV-2”, “elderly”, “children”, “pregnancy”, “athletes”. The result was 1684 publications which were later analyzed and selected depending on the inclusion/exclusion criteria. Among the obtained results in the research, most of the authors report a high prevalence of vitamin D deficiency worldwide and associate them to various pathologies, including COVID-19. Because is a fresh subject and although there are many reviews about this subject, it´s possible to see that there’s still a lot to investigate about vitamin D function whether in COVID-19 disease, whether in other pathologies, as the results sometimes may be inconsistent.
Description
Keywords
Vitamina D COVID-19 25-hidroxivitamina D 1,25-dihidroxivitamina D Calcidiol Calcitriol SARS-CoV-2 Vitamin D 25-hydroxyvitamin D 1,25 dihydroxy vitamin D