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Abstract(s)
The unique properties and characteristics of ocular tissues and the whole set of defence
mechanisms of the ocular globe make the instillation of ocular drugs into a difficult task with a low rate of
therapeutic response. One of the challenges for the new generation of ophthalmic pharmaceutical
formulations is to increase the bioavailability of drugs administered by the ocular route and, therefore, their
therapeutic efficacy. This can be achieved with the use of some strategies that provide an increase in the
formulation pre-corneal residence time, mucoadhesion and penetration across the eye tissues. Colloidal
carrier systems have been very successfully used for the selective and targeted delivery of drugs for several
routes of administration. In this context, nanoparticles prepared with specific polymers or lipids and coated,
dispersed or suspended in polymer solutions with mucoadhesion properties or in situ gelling properties will
be an excellent strategy that deserves attention and further research. In this review, the characteristics and
main properties of polymeric and lipid nanoparticles are discussed and examples and advantages of the
application of these colloidal carrier systems for the ophthalmic administration of drugs are presented. The
future directions of the research required in this specific field are also presented.
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Canadian Society for Pharmaceutical Sciences