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Chapter 4 - Organic nanocarriers for brain drug delivery

2021Book part Restricted access
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dc.contributor.authorLúcio, Marlene
dc.contributor.authorLopes, Carla Martins
dc.contributor.authorFernandes, Eduarda
dc.contributor.authorGonçalves, Hugo
dc.contributor.authorReal Oliveira, Maria Elisabete
dc.date.accessioned2021-09-13T12:18:51Z
dc.date.available2021-09-13T12:18:51Z
dc.date.issued2021
dc.description.abstractAlthough the blood–brain barrier remains a major barrier to drug delivery, organic nanocarriers (ONCs) have been demonstrated to be effective in targeting and delivering therapeutic agents to the brain and have provided promising preclinical outcomes. Because of their favourable physicochemical properties, such as biocompatible composition, nanometric dimensions, large surface area compared to volume and easily tuneable surfaces, ONCs have proven to be excellent transport vehicles capable of prolonging drug (or other therapeutic agents) circulation time and of addressing the challenges posed by numerous diseases affecting the brain.This chapter presents an overview of the different types of ONCs for brain delivery, including a description of their advantages and disadvantages, and a set of preclinical studies illustrating the most effective strategies for effective brain distribution. Biodegradation and bioelimination issues and future challenges for effective clinical translation are also addressed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMarlene Lúcio, Carla M. Lopes, Eduarda Fernandes, Hugo Gonçalves and M Elisabete C. D. Real Oliveira (2021). Chapter 4 - Organic nanocarriers for brain drug delivery. In: Carla Vitorino, Andreia Jorge and Alberto Pais (Eds). Nanoparticles for Brain Drug Delivery, pp. 75 – 160. Jenny Stanford Publishing Pte. Ltd., Taylor & Francis Group, Singaporept_PT
dc.identifier.doi10.1201/9781003119326pt_PT
dc.identifier.isbn978-981- 4877-31-2
dc.identifier.urihttp://hdl.handle.net/10284/10207
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherJenny Stanford Publishing Pte. Ltd., Taylor & Francis Grouppt_PT
dc.relationStrategic Funding [UID/ FIS/04650/2019], Project CONCERT [POCI- 01-0145-FEDER-032651 and PTDC/NAN-MAT/326512017], cofinanced by the European Regional Development Fund (ERDF), through COMPETE 2020, under Portugal 2020, and FCT I.P.pt_PT
dc.relation.publisherversionhttps://www.taylorfrancis.com/books/nanoparticles-brain-drug-delivery-carla-vitorino-andreia-jorge-alberto-pais/e/10.1201/9781003119326pt_PT
dc.subjectOrganic nanocarrierspt_PT
dc.subjectBrain deliverypt_PT
dc.titleChapter 4 - Organic nanocarriers for brain drug deliverypt_PT
dc.typebook part
dspace.entity.typePublication
oaire.citation.conferencePlaceSingaporept_PT
oaire.citation.endPage158pt_PT
oaire.citation.startPage73pt_PT
oaire.citation.titleNanoparticles for Brain Drug Deliverypt_PT
person.familyNameLopes
person.givenNameCarla
person.identifier.ciencia-id901D-160C-633E
person.identifier.orcid0000-0001-5080-032X
person.identifier.ridM-4689-2016
person.identifier.scopus-author-id26649517700
rcaap.rightsrestrictedAccesspt_PT
rcaap.typebookPartpt_PT
relation.isAuthorOfPublicationd2a48cfe-9258-4916-99be-bbcb710f6605
relation.isAuthorOfPublication.latestForDiscoveryd2a48cfe-9258-4916-99be-bbcb710f6605

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