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Miméticos do “glucagon-like peptide-1” (GLP-1) e o seu potencial farmacêutico no controlo da diabetes tipo 2 e da obesidade

2009Journal article Open access
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dc.contributor.authorAndreani, Tatiana
dc.contributor.authorSouto, Eliana B.
dc.contributor.authorSilva, Amélia M.
dc.contributor.authorLopes, Carla Martins
dc.date.accessioned2010-02-23T15:34:44Zpor
dc.date.accessioned2011-10-06T14:52:38Z
dc.date.available2010-02-23T15:34:44Zpor
dc.date.available2011-10-06T14:52:38Z
dc.date.issued2009por
dc.description.abstractA diabetes mellitus do tipo 2 é caracterizada pela resistência à insulina e pela disfunção das células β do pâncreas. Os péptidos gastrintestinais, “gastric inhibitory polypeptide” (GIP) e “glucagon-like peptide-1” (GLP-1), são hormonas incretinas que estimulam, maioritariamente, a produção de insulina pós-prandial. Formulações contendo GLP-1 possuem um grande potencial no tratamento desta doença. Porém, o GLP-1 é eficaz apenas quando administrado por via parentérica. Para o tratamento da diabetes mellitus tipo 2 são usados análogos do GLP‑ 1 ou miméticos da incretina os quais são eficazes por via subcutânea. The pathogenesis of diabetes mellitus type 2 includes insulin resistance and progressive β-cell dysfunction. The gastrointestinal peptides, gastric inhibitory polypeptide (GIP) and glucagon‑like peptide-1 (GLP-1), are incretin hormones which are responsible for the major part of postprandial insulin secretion. Formulations containing GLP-1 have a great potential in the treatment of diabetes mellitus type 2. Nonetheless, GLP-1 is only efficient by continuous parenteral administration. GLP-1 analogues or incretin mimetics, exendine-4, are active after subcutaneous injection and can be used in the treatment of diabetes mellitus of type 2.por
dc.identifier.citationRevista da Faculdade de Ciências da Saúde. Porto. ISSN 1646-0480. 6 (2009) 94-102.por
dc.identifier.issn1646-0480por
dc.identifier.urihttp://hdl.handle.net/10284/1276por
dc.language.isoporpor
dc.publisherEdições Universidade Fernando Pessoapor
dc.relation.ispartofseriesRevista da Faculdade de Ciências da Saúdepor
dc.relation.ispartofseries6por
dc.subjectIncretinapor
dc.subjectGLP-1por
dc.subjectIncretinomiméticospor
dc.subjectAnálogos do GLP-1por
dc.subjectDiabetes tipo 2por
dc.subjectIncretinpor
dc.subjectIncretin mimeticspor
dc.subjectAnalogues of GLP-1por
dc.subjectType 2 diabetespor
dc.titleMiméticos do “glucagon-like peptide-1” (GLP-1) e o seu potencial farmacêutico no controlo da diabetes tipo 2 e da obesidadepor
dc.typejournal article
dspace.entity.typePublication
person.familyNameAndreani
person.familyNameSouto
person.familyNameSilva
person.familyNameLopes
person.givenNameTatiana
person.givenNameEliana B.
person.givenNameAmélia
person.givenNameCarla
person.identifier1251023
person.identifier447329
person.identifier.ciencia-idF71E-31F5-DF0A
person.identifier.ciencia-id8D1B-21CC-90F7
person.identifier.ciencia-id241E-3956-0242
person.identifier.ciencia-id901D-160C-633E
person.identifier.orcid0000-0002-3794-8159
person.identifier.orcid0000-0002-9737-6017
person.identifier.orcid0000-0002-7524-9914
person.identifier.orcid0000-0001-5080-032X
person.identifier.ridL-9813-2014
person.identifier.ridJ-7128-2013
person.identifier.ridM-4689-2016
person.identifier.scopus-author-id36656962100
person.identifier.scopus-author-id8839435500
person.identifier.scopus-author-id35578752300
person.identifier.scopus-author-id26649517700
rcaap.rightsopenAccesspor
rcaap.typearticleen
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FCS - Número 06 (2009)