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Novos quimioterápicos obtidos a partir de organismos marinhos
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| PPG_23787 | 1.18 MB | Adobe PDF |
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O ecossistema marinho é uma fonte de grande biodiversidade. Assim sendo, desde meados do século XX, tornou-se um relevante campo de estudo para muitos investigadores. A exploração do meio aquático permitiu a obtenção de compostos de origem marinha que atuam nas mais variadas áreas tais como antivirais, antineoplásicos e antibacterianos. No entanto, nem todos se encontram comercializados devido à falta de resultados que permitam a sua aprovação. A grande maioria destes produtos está ainda em fase de estudos pré-clínicos e clínicos, apresentando, no entanto, propriedades bastante promissoras.
O cancro é uma doença com grande incidência a nível mundial levando a que a descoberta de novos compostos com propriedades antineoplásicas seja alvo de investigação preferencial. Neste momento, já se encontram aprovados três fármacos derivados de organismos marinhos para o tratamento de vários tipos de cancro, e muitas outras moléculas encontram-se repartidas nas diferentes fases de estudo pré-comercialização.
Este trabalho consiste numa revisão bibliográfica sobre o tema “novos quimioterápicos obtidos de organismos marinhos”, com especial incidência nos compostos antineoplásicos.
The marine ecosystem is a source of great biodiversity. Therefore, since the mid of the 20th century, it became a relevant field of study for many researchers. Exploring the aquatic environment provides different compounds of marine origin that can act in several areas such as antiviral, anticancer and antibacterial. Not all have the requirements to be commercialized mainly because there are still insufficient results to support their efficiency. The majority of these products are under study in clinical and preclinical trials presenting, however, very promising properties. Cancer is a high incidence worldwide disease that has led to the discovery of new compounds with antineoplastic properties that are the subject of prime research. At the moment, there are three drugs derived from marine organisms approved for several cancer treatments with a significant possibility of effective results of many others that are currently under different phases of the premarketing study. This work consists in a literature review of the topic "new chemotherapy obtained from marine organisms", with a particular focus on anticancer compounds.
The marine ecosystem is a source of great biodiversity. Therefore, since the mid of the 20th century, it became a relevant field of study for many researchers. Exploring the aquatic environment provides different compounds of marine origin that can act in several areas such as antiviral, anticancer and antibacterial. Not all have the requirements to be commercialized mainly because there are still insufficient results to support their efficiency. The majority of these products are under study in clinical and preclinical trials presenting, however, very promising properties. Cancer is a high incidence worldwide disease that has led to the discovery of new compounds with antineoplastic properties that are the subject of prime research. At the moment, there are three drugs derived from marine organisms approved for several cancer treatments with a significant possibility of effective results of many others that are currently under different phases of the premarketing study. This work consists in a literature review of the topic "new chemotherapy obtained from marine organisms", with a particular focus on anticancer compounds.
Descrição
Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas
Palavras-chave
Quimioterápico Produtos naturais marinhos Organismo marinho Cancro Antineoplásicos Mecanismo de ação Toxicidade Produtos farmacêuticos marinhos Tratamento Chemotherapeutic Marine natural products Marine organisms Cancer Antineoplastic Mechanism of action Toxicity Marine pharmaceuticals Treatment