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Publication
Manipulação do microbioma como adjuvante em tratamentos de cancro
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Abstract(s)
Os microrganismos presentes no microbioma humano coexistem em harmonia com o seu hospedeiro, mas podem, em determinadas circunstâncias, causar doença. O estudo do microbioma humano e, em particular, da microbiota intestinal está em franco desenvolvimento, tendo vindo a surgir novas evidências relativas à sua associação a diferentes patologias e ao seu papel na fisiologia humana.
O microbioma humano é caracterizado pela sua complexa plasticidade e um aumento do seu conhecimento é visto como promissor para o entendimento de vários processos e doenças, incluindo cancro. A sua relação com a saúde é muito abrangente e ainda pouco conhecida. Inúmeros estudos são desenvolvidos como forma de explorar novas estratégias de tratamento.
Além das intervenções já aplicadas, a manipulação do microbioma humano através do uso de probióticos e prebióticos, de uma combinação de ambos e do transplante de microbiota fecal (TMF), têm vindo a ser consideradas opções em relação e em complemento à antibioterapia para potenciar a eficácia dos tratamentos, reduzir a toxicidade e prevenir a carcinogénese.
Nesta revisão, são apresentadas formas de manipulação do microbioma como adjuvantes ao tratamento do cancro.
Microorganisms present in the human microbiome coexist in harmony with their host but can be the origin of disease under certain circumstances. Study of the human microbiome and particularly of the intestinal microbiota is developing, with new evidence emerging regarding its association with different pathologies and its role in human physiology. Human microbiome is characterized by its complex plasticity and an increase in knowledge is seen as promising for the understanding of various processes and diseases, including cancer. Human microbiome relationship with health is very wide and still little known. Numerous studies are being carried out as a way to explore new treatment strategies. In addition to the interventions already applied: manipulation of the human microbiome using probiotics and prebiotics, a combination of both and the fecal microbiota transplantation (FMT), are being considered options to support antibiotic therapy to enhance effectiveness of treatments, reduce toxicity and prevent carcinogenesis. In this paper, ways of manipulating the microbiome as a component of cancer treatment are presented.
Microorganisms present in the human microbiome coexist in harmony with their host but can be the origin of disease under certain circumstances. Study of the human microbiome and particularly of the intestinal microbiota is developing, with new evidence emerging regarding its association with different pathologies and its role in human physiology. Human microbiome is characterized by its complex plasticity and an increase in knowledge is seen as promising for the understanding of various processes and diseases, including cancer. Human microbiome relationship with health is very wide and still little known. Numerous studies are being carried out as a way to explore new treatment strategies. In addition to the interventions already applied: manipulation of the human microbiome using probiotics and prebiotics, a combination of both and the fecal microbiota transplantation (FMT), are being considered options to support antibiotic therapy to enhance effectiveness of treatments, reduce toxicity and prevent carcinogenesis. In this paper, ways of manipulating the microbiome as a component of cancer treatment are presented.
Description
Trabalho Complementar apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de licenciada em Ciências da Nutrição
Keywords
Microbioma humano Microbiota Probióticos Prebióticos Transplante de microbiota fecal Human microbiome Microbiota Cancer Probiotics Prebiotics Fecal microbiota transplantation