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Publication
Factores de adesão plaquetária e doença cardiovascular
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Advisor(s)
Abstract(s)
Atualmente as doenças cardiovasculares (DCVs) são uma
das principais causas da elevada taxa de mortalidade e
morbilidade nos países desenvolvidos.
As DCVs podem resultar de fatores ambientais e fatores
genéticos que contribuem para a patogénese e progressão destas doenças. Para além dos tradicionais
fatores de risco, também os fatores plaquetários que participam na ativação da cascata de coagulação são essenciais para o correto funcionamento do sistema hemostático. Quando este se encontra deficiente a manutenção da
integridade vascular e a minimização da perda de sangue
ficam comprometidas resultando na formação de trombos que, a longo prazo, originam a trombose.
Nowadays, cardiovascular diseases (CVDs) are one of the major factors causing high rate of mortality and morbidity in developed countries. CVDs result from changes in the cardiovascular system and may be due to environmental and genetic factors that contribute to the pathogenesis and progression of the disease. Besides the traditional risk factors, platelet factors involved in the activation of the coagulation cascade are essential for the correct functioning of the hemostatic system. When this system is deficient, the maintenance of vascular integrity and restriction of blood are compromised resulting in thrombus formation, which in long term, leads to thrombosis.
Nowadays, cardiovascular diseases (CVDs) are one of the major factors causing high rate of mortality and morbidity in developed countries. CVDs result from changes in the cardiovascular system and may be due to environmental and genetic factors that contribute to the pathogenesis and progression of the disease. Besides the traditional risk factors, platelet factors involved in the activation of the coagulation cascade are essential for the correct functioning of the hemostatic system. When this system is deficient, the maintenance of vascular integrity and restriction of blood are compromised resulting in thrombus formation, which in long term, leads to thrombosis.
Description
Keywords
Doenças cardiovasculares Fatores plaquetários Cascata de coagulação Cardiovascular diseases Platelet factors Coagulation cascade