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Etiologia, alterações metabólicas e tratamento do cancro da mama
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| Projeto de pós-graduação_37995 | 1.66 MB | Adobe PDF |
Orientador(es)
Resumo(s)
O cancro da mama representa um dos maiores desafios da oncologia moderna, sendo a principal causa de mortalidade por cancro em mulheres a nível mundial. A sua elevada heterogeneidade biológica e molecular exige uma compreensão aprofundada dos mecanismos que impulsionam a progressão tumoral. Este trabalho tem como objetivo analisar os fatores etiológicos, as principais reprogramações metabólicas e as abordagens terapêuticas atuais e emergentes para esta patologia. A metodologia baseou-se numa revisão bibliográfica seletiva, recorrendo a bases de dados científicas como PubMed, ScienceDirect e Google Scholar. Os resultados destacam que o metabolismo das células tumorais sofre alterações drásticas, nomeadamente através do efeito Warburg, do aumento da síntese lipídica e da dependência de aminoácidos como a glutamina, com o intuito de sustentar a rápida proliferação celular. Conclui-se que o sucesso do tratamento depende da caracterização molecular precisa do tumor, permitindo a aplicação de estratégias terapêuticas personalizadas para os diferentes subtipos moleculares, incluindo os tumores luminais, HER2+ e o triplo negativo (TNBC).
Breast cancer represents one of the greatest challenges in modern oncology, being the leading cause of cancer mortality among women worldwide. Its high biological and molecular heterogeneity requires a profound understanding of the mechanisms that drive tumor progression. This work aims to analyze the etiological factors, the main metabolic reprogrammings, and the current and emerging therapeutic approaches for this pathology. The methodology was based on a selective bibliographic review, using scientific databases such as PubMed, ScienceDirect, and Google Scholar. The results highlight that the metabolism of tumor cells undergoes drastic changes, namely through the Warburg effect, increased lipid synthesis, and dependency on amino acids such as glutamine, in order to sustain rapid cellular proliferation. It is concluded that treatment success depends on precise molecular characterization of the tumor, allowing for the application of personalized therapeutic strategies for the different molecular subtypes, including luminal, HER2+, and triple-negative tumors (TNBC).
Breast cancer represents one of the greatest challenges in modern oncology, being the leading cause of cancer mortality among women worldwide. Its high biological and molecular heterogeneity requires a profound understanding of the mechanisms that drive tumor progression. This work aims to analyze the etiological factors, the main metabolic reprogrammings, and the current and emerging therapeutic approaches for this pathology. The methodology was based on a selective bibliographic review, using scientific databases such as PubMed, ScienceDirect, and Google Scholar. The results highlight that the metabolism of tumor cells undergoes drastic changes, namely through the Warburg effect, increased lipid synthesis, and dependency on amino acids such as glutamine, in order to sustain rapid cellular proliferation. It is concluded that treatment success depends on precise molecular characterization of the tumor, allowing for the application of personalized therapeutic strategies for the different molecular subtypes, including luminal, HER2+, and triple-negative tumors (TNBC).
Descrição
Palavras-chave
Cancro da mama Cancro da mama triplo-negativo Reprogramação metabólica tumoral Metabolismo energético Biomarcadores metabólicos Terapias direcionadas Breast cancer Triple negative breast cancer Tumour metabolic reprogramming Energy metabolism Metabolic biomarkers