Repository logo
 
Publication

Adipokine gene single-nucleotide polymorphisms in portuguese obese adolescents: associations with plasma concentrations of adiponectin, resistin, IL-6, IL-1β, and TNF-α

2016Journal article Restricted access
Simple item page
dc.contributor.authorNascimento, Henrique
dc.contributor.authorVieira, Emília
dc.contributor.authorCoimbra, Susana
dc.contributor.authorCatarino, Cristina
dc.contributor.authorCosta, Elísio
dc.contributor.authorBronze-da-Rocha, Elsa
dc.contributor.authorRocha-Pereira, Petronila
dc.contributor.authorCarvalho, Márcia
dc.contributor.authorMansilha, Helena Ferreira
dc.contributor.authorRêgo, Carla
dc.contributor.authorSantos, Rosário dos
dc.contributor.authorSantos-Silva, Alice
dc.contributor.authorBelo, Luís
dc.date.accessioned2021-07-02T14:23:39Z
dc.date.available2021-07-02T14:23:39Z
dc.date.issued2016
dc.description.abstractBackground: The genetic contribution to obesity and to circulating adipokine levels has not been completely clarified. We aimed to evaluate adipokine genes' single-nucleotide polymorphism (SNP) prevalence and its association with circulating adipokine levels and risk factors for cardiovascular disease in an obese Portuguese pediatric population. Methods: Two hundred forty-eight obese adolescents (mean age 13.4 years old; 47.2% females) participated in a cohort study. We screened 12 SNPs by direct sequencing in five adipokine genes: adiponectin (ADIPOQ: rs16861194, rs17300539, rs266729, rs2241766, rs1501299), interleukin-1β (IL-1β; rs1143627), IL-6 (IL-6; rs1800795), tumor necrosis factor-α (TNF-α; rs1800629), and resistin (RETN; rs1862513, rs3219177, rs3745367, rs3745368). Biochemical analysis included determination of circulating adipokines, C-reactive protein (CRP) levels, lipid profile, and markers of insulin resistance. Results: Compared to males, females presented higher circulating levels of insulin, adiponectin, IL-6, resistin, and leptin concentrations, but lower TNF-α levels. No statistically significant differences were found for genotype or allelic distributions between genders. In the whole sample population, adiponectin levels were influenced by ADIPOQ rs17300539 (c.-1138G>A; lower in subjects with GG genotype). When only males were considered, IL-1β, IL-6, and TNF-α levels were associated with ADIPOQ rs1501299 (c.214 + 62G>T; higher in GG subjects). TNF-α concentrations were modulated by TNF-αrs1800629 (c.-488G>A; lower in GG males), RETN rs1862513 (c.-216C>G; higher in CC subjects), and RETN rs3219177 (c.118 + 39C>T; higher in CC subjects). Leptin levels were influenced by IL-1β rs1143627 (c.-118C>T) presenting TT individuals' lower levels. Conclusions: Our data demonstrate that in pediatric obese patients, some adipokine gene SNPs have an association with circulating adipokine levels and lipid profile.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.citationNascimento, H., Vieira, E. , Coimbra, S., Catarino, C., Costa, E., Bronze-da-Rocha, E., Rocha-Pereira, P., Carvalho, M., Mansilha, H.F., Rêgo, C., Santos, R., Santos-Silva, A. and Belo, L. (2016). Adipokine gene single-nucleotide polymorphisms in portuguese obese adolescents: associations with plasma concentrations of adiponectin, resistin, IL-6, IL-1β, and TNF-α. Childhood Obesity. pp.300-313. http://doi.org/10.1089/chi.2015.0235pt_PT
dc.identifier.doi10.1089/chi.2015.0235pt_PT
dc.identifier.eissn2153-2176
dc.identifier.issn2153-2168
dc.identifier.urihttp://hdl.handle.net/10284/10033
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMary Ann Liebert Inc.pt_PT
dc.relationThis work was funded by European Regional Development Fund (FEDER, Europe) funds through the Operational Competitiveness Programme (COMPETE, Portugal) and by National Funds through Fundação para a Ciência e a Tecnologia (FCT, Portugal) under the project FCOMP-01-0124-FEDER-028613 (PTDC/DTP-DES/ 0393/2012).pt_PT
dc.subjectAdipokinespt_PT
dc.subjectAdolescentpt_PT
dc.subjectCohort Studiespt_PT
dc.subjectFemalept_PT
dc.subjectGenetic predisposition to diseasept_PT
dc.subjectGenotypept_PT
dc.subjectHumanspt_PT
dc.subjectInsulin resistancept_PT
dc.subjectInterleukin-1βpt_PT
dc.subjectInterleukin-6pt_PT
dc.subjectMalept_PT
dc.subjectPediatric obesitypt_PT
dc.subjectPolymorphismpt_PT
dc.subjectPortugalpt_PT
dc.subjectResistinpt_PT
dc.subjectTumor necrosis factor-αpt_PT
dc.subjectSingle nucleotidept_PT
dc.titleAdipokine gene single-nucleotide polymorphisms in portuguese obese adolescents: associations with plasma concentrations of adiponectin, resistin, IL-6, IL-1β, and TNF-αpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage14pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleChildhood Obesitypt_PT
oaire.citation.volume12pt_PT
person.familyNameCarvalho
person.givenNameMarcia
person.identifier2017111
person.identifier.ciencia-id8B10-171E-E63E
person.identifier.orcid0000-0001-9884-4751
person.identifier.ridD-5999-2013
person.identifier.scopus-author-id7201413997
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3837b828-ba57-47f7-a811-cce65e4922c6
relation.isAuthorOfPublication.latestForDiscovery3837b828-ba57-47f7-a811-cce65e4922c6

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Adipokine gene single-nucleotide polymorphisms in portuguese obese adolescents.pdf
Size:
377.92 KB
Format:
Adobe Portable Document Format
Download

Collections

FCS - Artigos em Revistas Científicas Internacionais com Arbitragem Científica