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Adipokine gene single-nucleotide polymorphisms in portuguese obese adolescents: associations with plasma concentrations of adiponectin, resistin, IL-6, IL-1β, and TNF-α
dc.contributor.author | Nascimento, Henrique | |
dc.contributor.author | Vieira, Emília | |
dc.contributor.author | Coimbra, Susana | |
dc.contributor.author | Catarino, Cristina | |
dc.contributor.author | Costa, Elísio | |
dc.contributor.author | Bronze-da-Rocha, Elsa | |
dc.contributor.author | Rocha-Pereira, Petronila | |
dc.contributor.author | Carvalho, Márcia | |
dc.contributor.author | Mansilha, Helena Ferreira | |
dc.contributor.author | Rêgo, Carla | |
dc.contributor.author | Santos, Rosário dos | |
dc.contributor.author | Santos-Silva, Alice | |
dc.contributor.author | Belo, Luís | |
dc.date.accessioned | 2021-07-02T14:23:39Z | |
dc.date.available | 2021-07-02T14:23:39Z | |
dc.date.issued | 2016 | |
dc.description.abstract | Background: The genetic contribution to obesity and to circulating adipokine levels has not been completely clarified. We aimed to evaluate adipokine genes' single-nucleotide polymorphism (SNP) prevalence and its association with circulating adipokine levels and risk factors for cardiovascular disease in an obese Portuguese pediatric population. Methods: Two hundred forty-eight obese adolescents (mean age 13.4 years old; 47.2% females) participated in a cohort study. We screened 12 SNPs by direct sequencing in five adipokine genes: adiponectin (ADIPOQ: rs16861194, rs17300539, rs266729, rs2241766, rs1501299), interleukin-1β (IL-1β; rs1143627), IL-6 (IL-6; rs1800795), tumor necrosis factor-α (TNF-α; rs1800629), and resistin (RETN; rs1862513, rs3219177, rs3745367, rs3745368). Biochemical analysis included determination of circulating adipokines, C-reactive protein (CRP) levels, lipid profile, and markers of insulin resistance. Results: Compared to males, females presented higher circulating levels of insulin, adiponectin, IL-6, resistin, and leptin concentrations, but lower TNF-α levels. No statistically significant differences were found for genotype or allelic distributions between genders. In the whole sample population, adiponectin levels were influenced by ADIPOQ rs17300539 (c.-1138G>A; lower in subjects with GG genotype). When only males were considered, IL-1β, IL-6, and TNF-α levels were associated with ADIPOQ rs1501299 (c.214 + 62G>T; higher in GG subjects). TNF-α concentrations were modulated by TNF-αrs1800629 (c.-488G>A; lower in GG males), RETN rs1862513 (c.-216C>G; higher in CC subjects), and RETN rs3219177 (c.118 + 39C>T; higher in CC subjects). Leptin levels were influenced by IL-1β rs1143627 (c.-118C>T) presenting TT individuals' lower levels. Conclusions: Our data demonstrate that in pediatric obese patients, some adipokine gene SNPs have an association with circulating adipokine levels and lipid profile. | pt_PT |
dc.description.version | info:eu-repo/semantics/acceptedVersion | pt_PT |
dc.identifier.citation | Nascimento, H., Vieira, E. , Coimbra, S., Catarino, C., Costa, E., Bronze-da-Rocha, E., Rocha-Pereira, P., Carvalho, M., Mansilha, H.F., Rêgo, C., Santos, R., Santos-Silva, A. and Belo, L. (2016). Adipokine gene single-nucleotide polymorphisms in portuguese obese adolescents: associations with plasma concentrations of adiponectin, resistin, IL-6, IL-1β, and TNF-α. Childhood Obesity. pp.300-313. http://doi.org/10.1089/chi.2015.0235 | pt_PT |
dc.identifier.doi | 10.1089/chi.2015.0235 | pt_PT |
dc.identifier.eissn | 2153-2176 | |
dc.identifier.issn | 2153-2168 | |
dc.identifier.uri | http://hdl.handle.net/10284/10033 | |
dc.language.iso | eng | pt_PT |
dc.peerreviewed | yes | pt_PT |
dc.publisher | Mary Ann Liebert Inc. | pt_PT |
dc.relation | This work was funded by European Regional Development Fund (FEDER, Europe) funds through the Operational Competitiveness Programme (COMPETE, Portugal) and by National Funds through Fundação para a Ciência e a Tecnologia (FCT, Portugal) under the project FCOMP-01-0124-FEDER-028613 (PTDC/DTP-DES/ 0393/2012). | pt_PT |
dc.subject | Adipokines | pt_PT |
dc.subject | Adolescent | pt_PT |
dc.subject | Cohort Studies | pt_PT |
dc.subject | Female | pt_PT |
dc.subject | Genetic predisposition to disease | pt_PT |
dc.subject | Genotype | pt_PT |
dc.subject | Humans | pt_PT |
dc.subject | Insulin resistance | pt_PT |
dc.subject | Interleukin-1β | pt_PT |
dc.subject | Interleukin-6 | pt_PT |
dc.subject | Male | pt_PT |
dc.subject | Pediatric obesity | pt_PT |
dc.subject | Polymorphism | pt_PT |
dc.subject | Portugal | pt_PT |
dc.subject | Resistin | pt_PT |
dc.subject | Tumor necrosis factor-α | pt_PT |
dc.subject | Single nucleotide | pt_PT |
dc.title | Adipokine gene single-nucleotide polymorphisms in portuguese obese adolescents: associations with plasma concentrations of adiponectin, resistin, IL-6, IL-1β, and TNF-α | pt_PT |
dc.type | journal article | |
dspace.entity.type | Publication | |
oaire.citation.endPage | 14 | pt_PT |
oaire.citation.issue | 4 | pt_PT |
oaire.citation.startPage | 1 | pt_PT |
oaire.citation.title | Childhood Obesity | pt_PT |
oaire.citation.volume | 12 | pt_PT |
person.familyName | Carvalho | |
person.givenName | Marcia | |
person.identifier | 2017111 | |
person.identifier.ciencia-id | 8B10-171E-E63E | |
person.identifier.orcid | 0000-0001-9884-4751 | |
person.identifier.rid | D-5999-2013 | |
person.identifier.scopus-author-id | 7201413997 | |
rcaap.rights | closedAccess | pt_PT |
rcaap.type | article | pt_PT |
relation.isAuthorOfPublication | 3837b828-ba57-47f7-a811-cce65e4922c6 | |
relation.isAuthorOfPublication.latestForDiscovery | 3837b828-ba57-47f7-a811-cce65e4922c6 |
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