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Cognitive awareness after treatment for high-grade glioma

2021-09-20Journal article Open access
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dc.contributor.authorGiovagnoli, Anna Rita
dc.contributor.authorMeneses, Rute
dc.contributor.authorPaterlini, Chiara
dc.contributor.authorSilvani, Antonio
dc.contributor.authorBoiardi, Amerigo
dc.date.accessioned2023-09-11T15:11:21Z
dc.date.available2023-09-11T15:11:21Z
dc.date.issued2021-09-20
dc.date.updated2023-09-05T16:21:45Z
dc.description.abstractObjective: In patients with brain lesion, awareness of cognitive deficits is an important aspect of disease awareness. Glioblastoma (GBM) and anaplastic astrocytoma (AA) can cause cognitive deficits, but, to date, awareness of these deficits has not been documented. This study aimed to test cognitive awareness in these patients after the end of treatment. Methods: Fifty patients with GBM or AA were assessed using the Multiple Ability Self-Report Questionnaire (MASQ), State-Trait Anxiety Inventory (STAI), Self Rating Depression Scale (SRDS), and memory, attention, mental speed, abstract reasoning, and flexibility neuropsychological tests. Cognitive awareness was calculated as the concordance between the composite score of neuropsychological performance (PEC) and the total MASQ score. The controls were 48 healthy subjects. Analysis of variance and regression analysis compared subject groups and explored variables predicting perceived abilities. Results: Patients with GBM or AA showed similar attention, memory, and executive deficits compared with controls. Cognitive awareness was fair/full in 64% of patients. In the entire patients group, the worst MASQ scores were associated with neuropsychological deficits, anxiety, depression, and glioma location in the right hemisphere . In patients with fair/full awareness, MASQ scores were related to affective status and neuropsychological performance, whereas, in those with scarce/no awareness, they were related only to affective status. Conclusions: After treatment, many patients with GBM or AA are aware of their cognitive deficits. Anxiety, depression, and right hemisphere tumour exacerbate the perceived difficulties. This neurocognitive approach expands the behavioural phenotypes of high-grade gliomas and may have therapeutic implications over the course of the disease.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGiovagnoli, A. R., Meneses, R. F., Paterlini, C., Silvani, A., & Boiardi, A. (2021). Cognitive awareness after treatment for high-grade glioma. Clinical Neurology and Neurosurgery, 106953. https://doi.org/10.1016/j.clineuro.2021.106953pt_PT
dc.identifier.doi10.1016/j.clineuro.2021.106953pt_PT
dc.identifier.issn0303-8467
dc.identifier.slugcv-prod-2877283
dc.identifier.urihttp://hdl.handle.net/10284/12006
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.subjectCognitive awarenesspt_PT
dc.subjectPerceived cognitive abilitiespt_PT
dc.subjectNeuropsychological performancept_PT
dc.subjectHigh-grade gliomapt_PT
dc.subjectAffective statuspt_PT
dc.titleCognitive awareness after treatment for high-grade gliomapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage106953pt_PT
oaire.citation.titleClinical Neurology and Neurosurgerypt_PT
oaire.citation.volume210pt_PT
person.familyNameMeneses
person.givenNameRute F
person.identifierdCk1KLoAAAAJ
person.identifier.ciencia-id9210-F958-128F
person.identifier.orcid0000-0002-7189-3139
person.identifier.scopus-author-id23397995100
rcaap.cv.cienciaid9210-F958-128F | Rute F Meneses
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa9d1eeee-dfee-4191-a92a-bc03a44e6595
relation.isAuthorOfPublication.latestForDiscoverya9d1eeee-dfee-4191-a92a-bc03a44e6595

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