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Cancro das glândulas salivares: causas, metabolismo das células tumorais e abordagem do tratamento: revisão integrativa
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| Projeto de pós-graduação_41425 | 2.37 MB | Adobe PDF |
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O cancro das glândulas salivares constitui um conjunto de tumores raros, representando menos de 5% dos cancros da cabeça e do pescoço, mas distinguindo-se por uma heterogeneidade clínica, histológica e molecular significativa. Esta revisão integrativa tem como objetivo aprofundar o conhecimento sobre a fisiopatologia e os mecanismos etiológicos e metabólicos associados ao cancro das glândulas salivares, bem como analisar as principais opções terapêuticas atualmente disponíveis. Para tal, foi realizada uma revisão integrativa da literatura científica, baseada na análise crítica de 15 artigos selecionados pela sua pertinência metodológica e atualidade, a partir de bases de dados científicas como a PubMed e a ScienceDirect. A identificação e exclusão dos resultados foi efetuada de acordo com os critérios de inclusão e exclusão previamente estabelecidos. Este trabalho evidencia a necessidade de uma abordagem multidisciplinar e personalizada, que tenha em conta a grande diversidade biológica dos cancros das glândulas salivares. Destaca ainda as perspetivas promissoras trazidas pelos avanços recentes na biologia molecular, tanto para o diagnóstico precoce como para a otimização das estratégias terapêuticas.
Salivary gland cancer represents a group of rare tumors, accounting for less than 5% of head and neck cancers, but standing out due to significant clinical, histological, and molecular heterogeneity. This integrative review aims to deepen the understanding of the pathophysiology and the etiological and metabolic mechanisms associated with salivary gland cancer, as well as to analyze the main therapeutic options currently available. To this end, an integrative review of the scientific literature was conducted, based on the critical analysis of 15 articles selected for their methodological relevance and up-to-date content, using scientific databases such as PubMed and ScienceDirect. The identification and exclusion of results were carried out according to pre-established inclusion and exclusion criteria. This work highlights the need for a multidisciplinary and personalized approach that takes into account the wide biological diversity of salivary gland cancers. It also emphasizes the promising prospects brought by recent advances in molecular biology, both for early diagnosis and for the optimization of therapeutic strategies.
Salivary gland cancer represents a group of rare tumors, accounting for less than 5% of head and neck cancers, but standing out due to significant clinical, histological, and molecular heterogeneity. This integrative review aims to deepen the understanding of the pathophysiology and the etiological and metabolic mechanisms associated with salivary gland cancer, as well as to analyze the main therapeutic options currently available. To this end, an integrative review of the scientific literature was conducted, based on the critical analysis of 15 articles selected for their methodological relevance and up-to-date content, using scientific databases such as PubMed and ScienceDirect. The identification and exclusion of results were carried out according to pre-established inclusion and exclusion criteria. This work highlights the need for a multidisciplinary and personalized approach that takes into account the wide biological diversity of salivary gland cancers. It also emphasizes the promising prospects brought by recent advances in molecular biology, both for early diagnosis and for the optimization of therapeutic strategies.
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Cancro glândulas salivares Etiologia Metabolismo Tratamento Salivary gland cancer Etiology Treatment