Desenvolvimento de uma metodologia de produção de comprimidos trifásicos

Francisco, Jorge Manuel Pinheiro da Silva

http://hdl.handle.net/10284/2519

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Authors

Francisco, Jorge Manuel Pinheiro da Silva

Advisor(s)

Barata, Pedro

Abstract(s)

According to the concept of homeostasis, the body should not vary over time but variations have been demonstrated over a period of 24 hours in various body systems. These variations are designated as circadian rhythms. If the metabolic and physiological biochemical functions vary according to a rhythm, we can infer that a body has different needs according to the various stages in a cycle, thus, administrating a drug in a given time, the response may be different if the same dose is administrated at another time of day, thus was born the concept and the need for Chronotherapy. The objective of Chronotherapy systems, is to release different concentrations of the drug over a period of 24 hours according to biological need, so that, theoretically, be able to increase its effectiveness, and also reduce its adverse effects. For this treatment approach is often required special preparations of modified release tablets, and pulsatile release. This work aims to design and produce punches that somehow be able to produce a triplelayer tablet. The preparation of the tablets using the produced punches may be more or less complex depending on the method used, but the goal was achieved. Segundo o conceito de homeostase da fisiologia humana, o corpo não deveria sofrer variações durante o tempo, no entanto, foram demonstradas variações ao longo de um período de 24 horas em vários sistemas do organismo humano que se designaram por ritmos ou variações circadianas. Se as funções bioquímicas metabólicas e fisiológicas variam segundo um ritmo, pode-se inferir que um organismo tem necessidades diferentes segundo as distintas fases em que se encontra num ciclo, assim, ao administrar um fármaco em um determinado momento, é legítimo considerar que a resposta atingida por esse fármaco pode ser diferente, se este com a mesma dose for administrado noutra hora do dia, surgindo assim o conceito de Cronoterapia e a necessidade de sistemas cronoterapêuticos.