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Doenças neurodegenerativas e sua relação com alterações da cavidade oral: revisão narrativa
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 39583 | 1.21 MB | Adobe PDF |
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Abstract(s)
As doenças neurodegenerativas, como a doença de Alzheimer, a doença de Parkinson ou a Esclerose Lateral Amiotrófica (ELA), são caracterizadas pela perda progressiva de células neuronais e disfunção do sistema nervoso relacionada com diversos mecanismos, como agregação de proteínas, neuroinflamação, stress oxidativo e disfunção da neurotransmissão.
Para além da redução cognitiva, ocorre também a perda da autonomia pessoal, inviabilizando a realização das atividades da vida diária como nutrição e cuidados básicos de higiene oral.
Com este estudo pretende-se explorar a possível relação entre a presença de uma doença neurodegenerativa, como por exemplo a doença de Alzheimer, a doença de Parkinson e a ELA, e o desenvolvimento de patologias ou alterações na cavidade oral.
Para isso foi desenvolvida uma pesquisa da literatura, com recurso à base de dados PubMed e Google Académico. Esta pesquisa foi submetida a critérios de inclusão e exclusão, sendo selecionados 113 artigos, por serem os mais pertinentes para o desenvolvimento do tema.
Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, or Amyotrophic Lateral Sclerosis (ALS), are characterized by progressive loss of neuronal cells and dysfunction of the nervous system related to various mechanisms, such as protein aggregation, neuroinflammation, oxidative stress, and neurotransmission dysfunction. In addition to cognitive reduction, there is also the loss of personal autonomy, making it impossible to perform activities of daily living such as nutrition and basic oral hygiene care. This study aims to explore the possible relationship between the presence of a neurodegenerative disease, such as Alzheimer's disease, Parkinson's disease and ALS, and the development of pathologies or changes in the oral cavity. For this, a literature search was developed, using the PubMed and Google Scholar databases. This research was submitted to inclusion and exclusion criteria, and 113 articles were selected because they were the most pertinent to the development of the theme.
Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, or Amyotrophic Lateral Sclerosis (ALS), are characterized by progressive loss of neuronal cells and dysfunction of the nervous system related to various mechanisms, such as protein aggregation, neuroinflammation, oxidative stress, and neurotransmission dysfunction. In addition to cognitive reduction, there is also the loss of personal autonomy, making it impossible to perform activities of daily living such as nutrition and basic oral hygiene care. This study aims to explore the possible relationship between the presence of a neurodegenerative disease, such as Alzheimer's disease, Parkinson's disease and ALS, and the development of pathologies or changes in the oral cavity. For this, a literature search was developed, using the PubMed and Google Scholar databases. This research was submitted to inclusion and exclusion criteria, and 113 articles were selected because they were the most pertinent to the development of the theme.
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Keywords
Doenças neurodegenerativas Alterações orais Terapêutica farmacológica Doença de Alzheimer Doença de Parkinson Esclerose lateral amiotrófica Neurodegenerative diseases Oral changes Pharmacological therapy Alzheimer's disease Parkinson's disease Amyotrophic lateral sclerosis