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Therapeutic strategies for Alzheimer's and Parkinson's Diseases by means of drug delivery systems

2016Journal article Restricted access
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dc.contributor.authorCunha, S.
dc.contributor.authorAmaral, M.H.
dc.contributor.authorLobo, J.M. Sousa
dc.contributor.authorSilva, Ana Catarina
dc.date.accessioned2021-04-29T12:26:18Z
dc.date.available2021-04-29T12:26:18Z
dc.date.issued2016
dc.description.abstractAlzheimer's and Parkinson's diseases are prevalent neurodegenerative disorders worldwide, which are essentially related to aging. Within the remarkable era of nanomedicine, nowadays several delivery systems have been suggested to improve the treatment of these disorders, namely, liposomes, micelles, nanoparticles (polymeric, lipid, metallic and inorganic), exosomes, dendrimers and fullerenes. The advantage that has been claimed to these delivery systems is that they facilitate the passage of drugs through the blood brain barrier (BBB), enabling targeting before body degradation, and increasing therapeutic efficacy, comparied to conventional pharmaceutical dosage forms. This review article provides a state of the art regarding the drug delivery systems that have been studied for the treatment of Alzheimer's and Parkinson's diseases. It begins with a brief description of the central nervous system (CNS) and the mechanisms involved in the development of these diseases. Later, some examples of drugs used in the treatment of these neurodegenerative diseases are presented, which are currently available in conventional pharmaceutical dosage forms, and in new drug delivery systems that are under development.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.2174/0929867323666160824162401pt_PT
dc.identifier.issn0929-8673
dc.identifier.urihttp://hdl.handle.net/10284/9827
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBentham Science Publisherspt_PT
dc.subjectAlzheimer’s diseasept_PT
dc.subjectParkinson’s diseasept_PT
dc.subjectLiposomespt_PT
dc.subjectMicellespt_PT
dc.subjectNanoparticlespt_PT
dc.subjectExosomespt_PT
dc.subjectDendrimerspt_PT
dc.subjectFullerenespt_PT
dc.titleTherapeutic strategies for Alzheimer's and Parkinson's Diseases by means of drug delivery systemspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage14pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleCurrent Medicinal Chemistrypt_PT
oaire.citation.volume23pt_PT
person.familyNameSilva
person.givenNameAna Catarina
person.identifier953153
person.identifier.ciencia-id5C1D-ED22-0D64
person.identifier.orcid0000-0001-6923-0232
person.identifier.ridF-1875-2017
person.identifier.scopus-author-id57028697500
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication67e7f707-32ec-444a-a20d-a17f8e6e7c21
relation.isAuthorOfPublication.latestForDiscovery67e7f707-32ec-444a-a20d-a17f8e6e7c21

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