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Biossegurança, eficácia clínica e auto-perceção na aplicação de toxina botulínica em músculos da mimica peri-orais: investigação
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A medicina estética tem registado um crescimento expressivo no século XXI, com destaque para os procedimentos minimamente invasivos, entre os quais a aplicação de toxina botulínica tipo A ocupa lugar central. Embora a sua utilização esteja bem documentada no terço superior da face, persistem lacunas relativamente à aplicação na região perioral, sobretudo quanto à eficácia clínica por grupo muscular, biossegurança e impacto psicossocial. O presente estudo avaliou a aplicação de BTX-A em músculos associados à dinâmica do sorriso e da região perioral — levantador do lábio superior e da asa do nariz (LLSAN), zigomático menor, mentalis, depressor anguli oris e orbicularis oris — em 53 participantes do sexo feminino, com idades entre 20 e 65 anos. Tratou-se de um estudo clínico quase-experimental do tipo antes-depois, sem grupo controlo, com avaliação clínica pré e pós-tratamento (10-15 dias). A eficácia clínica foi analisada por grupo muscular; a biossegurança foi avaliada pelo registo de efeitos adversos; e a auto-perceção foi medida com o questionário FACE-Q. Os resultados sugerem maior resposta clínica nos grupos sorriso gengival, mento e DAO, enquanto o grupo orbicularis oris apresentou efeito reduzido e elevada variabilidade. O procedimento mostrou um perfil de segurança favorável, com manifestações ligeiras e transitórias, e observaram-se melhorias nos indicadores de satisfação e bem-estar psicossocial. Conclui-se que a BTX-A pode constituir uma opção útil na harmonização orofacial, mas os resultados devem ser interpretados com prudência, atendendo à ausência de grupo controlo, à amostra exclusivamente feminina, ao curto seguimento e à heterogeneidade entre grupos musculares.
Aesthetic medicine has grown significantly in the 21st century, particularly through minimally invasive procedures such as botulinum toxin type A. Although its use is well documented in the upper face, evidence regarding the perioral region remains limited, especially in relation to muscle-specific clinical efficacy, biosafety, and psychosocial impact. This study evaluated the use of BTX-A in muscles associated with smile dynamics and the perioral region — levator labii superioris alaeque nasi (LLSAN), zygomaticus minor, mentalis, depressor anguli oris, and orbicularis oris — in 53 female participants aged 20-65 years. The design was a quasi-experimental before-after clinical study without a control group, with pre- and post-treatment assessment after 10-15 days. Clinical efficacy was analysed by muscle group; biosafety was assessed through adverse-event recording; and self-perception was measured using the FACE-Q questionnaire. The results suggest greater clinical response in the gummy smile, chin, and DAO groups, whereas the orbicularis oris group showed limited effect and greater variability. The procedure showed a favourable safety profile, with mild and transient manifestations, and improvements were observed in satisfaction and psychosocial well-being indicators. BTX-A may therefore represent a useful option in orofacial harmonization; however, the findings should be interpreted cautiously in light of the lack of a control group, the exclusively female sample, the short follow-up period, and the heterogeneity between muscle groups.
Aesthetic medicine has grown significantly in the 21st century, particularly through minimally invasive procedures such as botulinum toxin type A. Although its use is well documented in the upper face, evidence regarding the perioral region remains limited, especially in relation to muscle-specific clinical efficacy, biosafety, and psychosocial impact. This study evaluated the use of BTX-A in muscles associated with smile dynamics and the perioral region — levator labii superioris alaeque nasi (LLSAN), zygomaticus minor, mentalis, depressor anguli oris, and orbicularis oris — in 53 female participants aged 20-65 years. The design was a quasi-experimental before-after clinical study without a control group, with pre- and post-treatment assessment after 10-15 days. Clinical efficacy was analysed by muscle group; biosafety was assessed through adverse-event recording; and self-perception was measured using the FACE-Q questionnaire. The results suggest greater clinical response in the gummy smile, chin, and DAO groups, whereas the orbicularis oris group showed limited effect and greater variability. The procedure showed a favourable safety profile, with mild and transient manifestations, and improvements were observed in satisfaction and psychosocial well-being indicators. BTX-A may therefore represent a useful option in orofacial harmonization; however, the findings should be interpreted cautiously in light of the lack of a control group, the exclusively female sample, the short follow-up period, and the heterogeneity between muscle groups.
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Harmonização Orofacial Toxina botulínica Anatomia perioral Sorriso gengival Rugas periorais Mento Orofacial Harmonization Botulinum toxin Perioral anatomy Gummy smile Perioral wrinkles Chin