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Green tea: a promising anticancer agent for renal cell carcinoma

2010Journal article Restricted access
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dc.contributor.authorCarvalho, Márcia
dc.contributor.authorJerónimo, Carmen
dc.contributor.authorValentão, Patrícia
dc.contributor.authorAndrade, Paula B.
dc.contributor.authorSilva, Branca M.
dc.date.accessioned2021-07-02T16:34:41Z
dc.date.available2021-07-02T16:34:41Z
dc.date.issued2010
dc.description.abstractRenal cell carcinoma (RCC) is one of the most lethal amongst the urologic malignancies, comprising three percent of all human neoplasms, and its incidence appears to be rising. RCC is refractory to both chemotherapy and radiotherapy. Therefore, the discovery of new strategies for therapeutic intervention remains a priority. Green tea (Camellia sinensis) and tea polyphenols have been proposed to exert protective effects against several types of cancer, based on preclinical and clinical trial data; however, the anticarcinogenic activity of green tea towards RCC is unknown. In this study, a targeted metabolite analysis on a green tea leaves methanolic extract was performed by HPLC/DAD and the antiproliferative activity of the extract was assayed using human renal cancer cell lines A-498 and 769-P. The total phenolic content was very high (31.8% of methanolic extract), and the main compounds were flavan-3-ols (94.3% of the total phenolic content), and especially (−)-epigallocatechin-3-gallate (35.9% of the total phenolic content). In addition, two methylxanthines – theophylline and caffeine – were also present in the extract, caffeine being the most abundant. Green tea extract strongly inhibited the growth of both RCC cell lines in a concentration-dependent manner, with IC50 values of 54 ± 10 and 129 ± 28 μg/ml for A-498 and 769-P cells, respectively. This is the first report showing that green tea is likely to be an effective anticancer agent for renal cell carcinoma.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.foodchem.2010.02.014pt_PT
dc.identifier.issn0308-8146
dc.identifier.urihttp://hdl.handle.net/10284/10044
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectGreen teapt_PT
dc.subjectCamellia sinensispt_PT
dc.subjectRenal cell carcinomapt_PT
dc.subjectPolyphenolspt_PT
dc.subjectAntiproliferative activitypt_PT
dc.titleGreen tea: a promising anticancer agent for renal cell carcinomapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage54pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage49pt_PT
oaire.citation.titleFood Chemistrypt_PT
oaire.citation.volume122pt_PT
person.familyNameCarvalho
person.familyNameSilva
person.givenNameMarcia
person.givenNameBranca Maria
person.identifier2017111
person.identifier1033309
person.identifier.ciencia-id8B10-171E-E63E
person.identifier.ciencia-idBD1F-B24D-89A9
person.identifier.orcid0000-0001-9884-4751
person.identifier.orcid0000-0002-5610-8024
person.identifier.ridD-5999-2013
person.identifier.scopus-author-id7201413997
person.identifier.scopus-author-id7005615589
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3837b828-ba57-47f7-a811-cce65e4922c6
relation.isAuthorOfPublication26c68872-1849-4895-a48d-72ccffbc02df
relation.isAuthorOfPublication.latestForDiscovery26c68872-1849-4895-a48d-72ccffbc02df

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