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Publication
Sistemas coloidais utilizados para a imunização por via intranasal
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| PPG_27819 | 1.53 MB | Adobe PDF |
Advisor(s)
Abstract(s)
A vacinação é um dos métodos mais adequado para proteger a população em geral de infeções. No entanto, a contínua evolução e a resistência dos microrganismos aos métodos atualmente existentes traduz-se na necessidade de inovar nesta área.
A imunização através das mucosas, particularmente por via intranasal, apresenta diversas vantagens, relativamente à imunização por outras vias, particularmente no que concerne à potenciação da resposta imunológica, sendo um tema amplamente estudado por vários investigadores.
Na presente dissertação é analisada a influência de diversos sistemas coloidais na encapsulação de antigénios e/ou adjuvantes utilizados para a imunização intranasal. Os estudos in vivo mais recentes envolvendo nanopartículas, micelas, lipossomas, arqueossomas, nanotubos de carbono ou partículas ‘virus-like’ são apresentados, bem como as barreiras fisiológicas, farmacêuticas e regulamentares que estes sistemas têm que ultrapassar para atingirem o sucesso no mercado e na adesão da população.
Despite being one of the most effective ways to protect the world population against infections, the continuous emergence and resistance of pathogens to vaccination highlights the constant need of innovation on this field. Immunization through the mucosa, particularly through the intranasal route, has several advantages over immunization by other routes, particularly with regard to the potentiating the immune response, being a topic widely studied by several investigators. This dissertation provides an overview on recent studies evolving particulate systems for antigens delivery, with or without adjuvants, to the airway mucosa. The most recent and relevant in vivo studies with nanoparticles, micelles, liposomes, archaesomes, carbon nanotubes or virus-like particles are presented, as well as physical, pharmaceutical and regulatory barriers that have to be overtaken by these particulate systems to hit clinical and commercial success.
Despite being one of the most effective ways to protect the world population against infections, the continuous emergence and resistance of pathogens to vaccination highlights the constant need of innovation on this field. Immunization through the mucosa, particularly through the intranasal route, has several advantages over immunization by other routes, particularly with regard to the potentiating the immune response, being a topic widely studied by several investigators. This dissertation provides an overview on recent studies evolving particulate systems for antigens delivery, with or without adjuvants, to the airway mucosa. The most recent and relevant in vivo studies with nanoparticles, micelles, liposomes, archaesomes, carbon nanotubes or virus-like particles are presented, as well as physical, pharmaceutical and regulatory barriers that have to be overtaken by these particulate systems to hit clinical and commercial success.
Description
Keywords
Vacina Imunização nasal Sistemas coloidais Nanopartícula de sílica Nanopartícula de ouro Lipossoma Micela Virossoma Arqueossoma Nanotubo de carbono Partícula ‘virus-like’ Resposta imunológica Antigénio Adjuvante Vaccine Immunization Nasal Particulate systems Silica nanoparticle Gold nanoparticle Liposome Micelle Virosome Archaesome Carbon nanotube Virus-like particle Immune response Antigen Adjuvant