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Evaluation of immunoexpression and MDR1 promoter methylation levels in prostatic tissue samples

2008Journal article Open access
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dc.contributor.authorMoura, Inêspor
dc.contributor.authorCosta, Vera L.por
dc.contributor.authorPais, Irenepor
dc.contributor.authorRibeiro, Franclim R.por
dc.contributor.authorHenrique, Ruipor
dc.contributor.authorJerónimo, Carmen
dc.date.accessioned2009-02-12T09:44:46Zpor
dc.date.accessioned2011-10-06T14:52:33Z
dc.date.available2009-02-12T09:44:46Zpor
dc.date.available2011-10-06T14:52:33Z
dc.date.issued2008por
dc.description.abstractOs objectivos deste estudo foram: (1) Determinar os níveis de metilação do promotor do MDR1 em tecido prostático com adenocarcinoma (CaP), neoplasia intraepitelial prostática de alto grau (HGPIN), hiperplasia benigna (BPH) e tecido morfologicamente normal (MNP). (2) Correlacionar os níveis de metilação com a imunoexpressão da gp-P. Os nossos resultados demonstram que a hipermetilação do MDR1 constitui um mecanismo eficaz de regulação da sua expressão. Estudos futuros permitirão avaliar o impacto destes resultados na terapêutica do cancro da próstata. Our aims were: (1) To determine the MDR1 methylation levels in tissue of Prostate cancer (PCa), high grade prostatic intraepithelial neoplasia (HGPIN), benign prostatic hyperplasia (BPH) and morphologically normal prostate tissue (MNP); (2) to correlate the methylation levels of the MDR1 promoter with the immunoexpression of P-gp. Our results demonstrate that MDR1 hypermethylation constitutes an effective mechanism of P-gp expression regulation. Future studies will be able to evaluate the impact of these results in the treatment of PCa patients.por
dc.identifier.citationRevista da Faculdade de Ciências da Saúde. Porto. ISSN 1646-0480. 5 (2008) 124-132.por
dc.identifier.issn1646-0480por
dc.identifier.urihttp://hdl.handle.net/10284/939por
dc.language.isoporpor
dc.publisherEdições Universidade Fernando Pessoapor
dc.relation.ispartofseriesRevista da Faculdade de Ciências da Saúdepor
dc.relation.ispartofseries5por
dc.subjectCancro da próstatapor
dc.subjectMDR1por
dc.subjectgp-Ppor
dc.subjectMetilação do promotorpor
dc.subjectEpigéneticapor
dc.subjectProstate cancerpor
dc.subjectPromoter methylationpor
dc.subjectEpigeneticspor
dc.titleEvaluation of immunoexpression and MDR1 promoter methylation levels in prostatic tissue samplespor
dc.typejournal article
dspace.entity.typePublication
person.familyNameJerónimo
person.givenNameCarmen
person.identifier.ciencia-idCE16-29CB-EDD1
person.identifier.orcid0000-0003-4186-5345
person.identifier.scopus-author-id57197057169
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationdb2de1f6-31a6-4d90-9b0b-217f234dcbe5
relation.isAuthorOfPublication.latestForDiscoverydb2de1f6-31a6-4d90-9b0b-217f234dcbe5

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FCS - Número 05 (2008)