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Mycobacterium avium subsp. paratuberculosis: características e infeção
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A mycobacterium avium subsp. paratuberculosis (MAP), é uma subespécie do complexo M. avium, que provoca a doença de Johne, uma enterite crónica em ruminantes e suspeita-se estar envolvida no desenvolvimento doença inflamatória intestinal crónica em humanos particularmente, na doença de Crohn. Devido a complexidade desta micobactéria é, importante o desenvolvimento de novas técnicas poderosas para a sua deteção e identificação, de maneira a obterem-se respostas mais concretas na associação desta subespécie de micobactéria a doença de Crohn. Neste trabalho através de uma revisão bibliográfica, descreve, primeiramente num contexto geral, a taxonomia e características gerais das micobactérias, focalizando-se numa abordagem sobre MAP, a sua capacidade de causar doença inflamatória intestinal, o diagnóstico e tratamento desta doença, e a importância que esta subespécie pode ter no desenvolvimento da doença de Crohn em particular. A obtenção de cura total dos doentes com CD seria um notável desenvolvimento no mundo da medicina. Para isso é necessária a prossecução dos estudos e a obtenção de conclusões mais objetivas.
The mycobacterium avium subsp. paratuberculosis (MAP), is a subspecies of the M. avium complex, which causes Johne's disease, a chronic ruminant enteritis and is suspected to be involved in the development of chronic inflammatory bowel disease in humans, particularly Crohn's disease. Due to the complexity of this mycobacterium, its important to develop powerful new techniques for its detection and identification in order to obtain more concrete responses in the association of this mycobacterial subspecies with Crohn's disease. In this paper, through a literature review, it describes, firstly in a general context, the taxonomy and general characteristics of mycobacteria, focusing on an approach to MAP, its ability to cause inflammatory bowel disease, the diagnosis and treatment of this disease, and the importance that this subspecies may have in the development of Crohn's disease in particular. Achieving total cure for CD patients would be a remarkable development in the medical world. This requires further studies and more objective conclusions.
The mycobacterium avium subsp. paratuberculosis (MAP), is a subspecies of the M. avium complex, which causes Johne's disease, a chronic ruminant enteritis and is suspected to be involved in the development of chronic inflammatory bowel disease in humans, particularly Crohn's disease. Due to the complexity of this mycobacterium, its important to develop powerful new techniques for its detection and identification in order to obtain more concrete responses in the association of this mycobacterial subspecies with Crohn's disease. In this paper, through a literature review, it describes, firstly in a general context, the taxonomy and general characteristics of mycobacteria, focusing on an approach to MAP, its ability to cause inflammatory bowel disease, the diagnosis and treatment of this disease, and the importance that this subspecies may have in the development of Crohn's disease in particular. Achieving total cure for CD patients would be a remarkable development in the medical world. This requires further studies and more objective conclusions.
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Keywords
Micobactéria Mycobacterium avium subsp. paratuberculosis MAP Complexo mycobacterium avium MAC Doenças inflamatórias intestinais Doença de Johne Doença de Crohn Colite ulcerosa Micobactérias não tuberculosas NTM Mycobacteria Mycobacterium avium subsp. paratuberculosis MAP Mycobacterium avium complex MAC Inflammatory bowel diseases Johne's disease Crohn's disease Ulcerative colitis Non-tuberculous mycobacteria NTM