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Lipid-based nanocarriers as an alternative for oral delivery of poorly water - soluble drugs: peroral and mucosal routes

2012-09-01Journal article Restricted access
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dc.contributor.authorSilva, Ana Catarina
dc.contributor.authorSantos, D.
dc.contributor.authorFerreira, D.
dc.contributor.authorLopes, Carla Martins
dc.date.accessioned2020-10-14T15:43:04Z
dc.date.available2020-10-14T15:43:04Z
dc.date.issued2012-09-01
dc.date.updated2020-07-24T16:12:38Z
dc.description.abstractThe hydrophobic character of most drug molecules and their potential for degradation under the hostile environment of the gastrointestinal tract (GIT) constitutes the main obstacle in the development of a successful oral drug delivery system, since these are related to limitations of bioavailability and absorption processes. However, according to the advantages of the oral route, alternative ways of drug administration in the oral cavity should be considered. In this context, it is essential to have a systematic knowledge of the GIT and the oral cavity components, for a better understanding of the processes taking place during the oral administration of drugs. This review gives an overview of those anatomical and physiological features and elucidates about the current approaches employed to enhance the bioavailability of oral poorly water-soluble drugs. Strategies including the uses of lipid-based nanocarriers, such as nanoemulsions, liposomes and lipid nanoparticles are discussed, considering their ability to improve solubility, dissolution kinetics, absorption and, consequently, biopharmaceutical properties. Some toxicological concerns are also highlighted.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.2174/092986712803251584pt_PT
dc.identifier.eid2-s2.0-84865758788
dc.identifier.issn1875-533X
dc.identifier.slugcv-prod-1252838
dc.identifier.urihttp://hdl.handle.net/10284/9057
dc.language.isoengpt_PT
dc.publisherBentham Science Publisherspt_PT
dc.subjectGastrointestinal tractpt_PT
dc.subjectLipid-based nanocarrierspt_PT
dc.subjectLiposomespt_PT
dc.subjectLipid nanoparticlespt_PT
dc.subjectSolid lipid nanoparticlespt_PT
dc.subjectNanostructured lipid carrierspt_PT
dc.subjectNanoemulsionspt_PT
dc.subjectOral administrationpt_PT
dc.subjectOral cavity administrationpt_PT
dc.subjectPeroral administrationpt_PT
dc.subjectPoorly water-soluble drugspt_PT
dc.subjectToxicitypt_PT
dc.titleLipid-based nanocarriers as an alternative for oral delivery of poorly water - soluble drugs: peroral and mucosal routespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage4510pt_PT
oaire.citation.issue26pt_PT
oaire.citation.startPage4495pt_PT
oaire.citation.titleCurrent Medicinal Chemistrypt_PT
oaire.citation.volume19pt_PT
person.familyNameSilva
person.familyNameLopes
person.givenNameAna Catarina
person.givenNameCarla
person.identifier953153
person.identifier.ciencia-id5C1D-ED22-0D64
person.identifier.ciencia-id901D-160C-633E
person.identifier.orcid0000-0001-6923-0232
person.identifier.orcid0000-0001-5080-032X
person.identifier.ridF-1875-2017
person.identifier.ridM-4689-2016
person.identifier.scopus-author-id57028697500
person.identifier.scopus-author-id26649517700
rcaap.cv.cienciaid901D-160C-633E | Carla Martins Lopes
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication67e7f707-32ec-444a-a20d-a17f8e6e7c21
relation.isAuthorOfPublicationd2a48cfe-9258-4916-99be-bbcb710f6605
relation.isAuthorOfPublication.latestForDiscoveryd2a48cfe-9258-4916-99be-bbcb710f6605

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