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Lipid-based nanocarriers as an alternative for oral delivery of poorly water - soluble drugs: peroral and mucosal routes
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Orientador(es)
Resumo(s)
The hydrophobic character of most drug molecules and their potential for degradation under the hostile environment of the gastrointestinal tract (GIT) constitutes the main obstacle in the development of a successful oral drug delivery system, since these are related to limitations of bioavailability and absorption processes. However, according to the advantages of the oral route, alternative ways of drug administration in the oral cavity should be considered. In this context, it is essential to have a systematic knowledge of the GIT and the oral cavity components, for a better understanding of the processes taking place during the oral administration of drugs. This review gives an overview of those anatomical and physiological features and elucidates about the current approaches employed to enhance the bioavailability of oral poorly water-soluble drugs. Strategies including the uses of lipid-based nanocarriers, such as nanoemulsions, liposomes and lipid nanoparticles are discussed, considering their ability to improve solubility, dissolution kinetics, absorption and, consequently, biopharmaceutical properties. Some toxicological concerns are also highlighted.
Descrição
Palavras-chave
Gastrointestinal tract Lipid-based nanocarriers Liposomes Lipid nanoparticles Solid lipid nanoparticles Nanostructured lipid carriers Nanoemulsions Oral administration Oral cavity administration Peroral administration Poorly water-soluble drugs Toxicity
Contexto Educativo
Citação
Editora
Bentham Science Publishers