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Publication
Papel do adipócito na inflamação do doente obeso
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Abstract(s)
Objetivo: Descrever a evidência atual sobre o papel do adipócito na inflamação do doente obeso. Metodologia: Foram pesquisados artigos que descrevessem o papel do adipócito na inflamação do doente obeso. Foi utilizada a base de dados do PubMed com os termos de pesquisa: adipocyte, inflammation e obesity. Foram obtidos 1204 artigos, dos quais foram utilizados 30 artigos. Resultados: O tecido adiposo é um tecido complexo e dinâmico, capaz de responder a vários estímulos. Na situação de obesidade, onde existe um balanço energético positivo, o adipócito responde a este estímulo e é capaz de comportar-se como uma célula do sistema imunológico, caracterizada pela secreção de adipocinas. A secreção de adipocinas é responsável por modular a inflamação no tecido adiposo na patologia da obesidade. Conclusão: A literatura científica atual fornece uma maior compreensão dos processos inflamatórios relacionados à obesidade, sendo o adipócito, peça central e importante na regulação destes processos. Alguns mecanismos imunológicos ainda não estão totalmente esclarecidos, portanto, pesquisas neste âmbito são necessárias.
Aims: Describe the current evidence on the role of the adipocyte in inflammation in obese patients. Methodology: Articles describing the role of the adipocyte in inflammation in obese patients were searched. The PubMed database was used with the search terms: adipocyte, inflammation and obesity. 1204 articles were obtained, of which 30 articles were used. Results: Adipose tissue is a complex and dynamic tissue, capable of responding to various stimuli. In a situation of obesity, where there is a positive energy balance, the adipocyte responds to this stimulus and is able to behave like a cell of the immune system, characterized by the secretion of adipokines. The secretion of adipokines is responsible for modulating inflammation in adipose tissue in the pathology of obesity. Conclusions: Current scientific literature provides a greater understanding of the inflammatory processes related to obesity, with the adipocyte being a central and important piece in the regulation of these processes. Some immunological mechanisms are not yet fully understood, therefore, research in this area is necessary.
Aims: Describe the current evidence on the role of the adipocyte in inflammation in obese patients. Methodology: Articles describing the role of the adipocyte in inflammation in obese patients were searched. The PubMed database was used with the search terms: adipocyte, inflammation and obesity. 1204 articles were obtained, of which 30 articles were used. Results: Adipose tissue is a complex and dynamic tissue, capable of responding to various stimuli. In a situation of obesity, where there is a positive energy balance, the adipocyte responds to this stimulus and is able to behave like a cell of the immune system, characterized by the secretion of adipokines. The secretion of adipokines is responsible for modulating inflammation in adipose tissue in the pathology of obesity. Conclusions: Current scientific literature provides a greater understanding of the inflammatory processes related to obesity, with the adipocyte being a central and important piece in the regulation of these processes. Some immunological mechanisms are not yet fully understood, therefore, research in this area is necessary.
Description
Trabalho Complementar apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de licenciada em Ciências da Nutrição
Keywords
Adipócito Inflamação Obesidade Adipocyte Inflammation Obesity