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Metabolomics analysis for biomarker discovery: advances and challenges

2012Journal article Restricted access
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dc.contributor.authorMonteiro, M.S.
dc.contributor.authorCarvalho, Márcia
dc.contributor.authorBastos, M.L.
dc.contributor.authorGuedes de Pinho, Paula
dc.date.accessioned2021-07-02T15:52:37Z
dc.date.available2021-07-02T15:52:37Z
dc.date.issued2012
dc.description.abstractOver the last decades there has been a change in biomedical research with the search for single genes, transcripts, proteins, or metabolites being substituted by the coverage of the entire genome, transcriptome, proteome, and metabolome with the "omics" approaches. The emergence of metabolomics, defined as the comprehensive analysis of all metabolites in a system, is still recent compared to other "omics" fields, but its particular features and the improvement of both analytical techniques and pattern recognition methods has contributed greatly to its increasingly use. The feasibility of metabolomics for biomarker discovery is supported by the assumption that metabolites are important players in biological systems and that diseases cause disruption of biochemical pathways, which are not new concepts. In fact, metabolomics, meaning the parallel assessment of multiple metabolites, has been shown to have benefits in various clinical areas. Compared to classical diagnostic approaches and conventional clinical biomarkers, metabolomics offers potential advantages in sensitivity and specificity. Despite its potential, metabolomics still retains several intrinsic limitations which have a great impact on its widespread implementation - these limitations in biological and experimental measurements. This review will provide an insight to the characteristics, strengths, limitations, and recent advances in metabolomics, always keeping in mind its potential application in clinical/ health areas as a biomarker discovery tool.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.2174/0929867311320020006pt_PT
dc.identifier.eissn1875-533X
dc.identifier.issn0929-8673
dc.identifier.urihttp://hdl.handle.net/10284/10038
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBentham Science Publisherspt_PT
dc.subjectMetabolomicspt_PT
dc.subjectMetabolomept_PT
dc.subjectMetabolitespt_PT
dc.subjectBiomarkerspt_PT
dc.subjectSystems biologypt_PT
dc.subjectMetabolomic analysispt_PT
dc.subjectMass spectrometrypt_PT
dc.subjectNMRpt_PT
dc.subjectMetabolic profilingpt_PT
dc.subjectUntargeted metabolomicspt_PT
dc.subjectAdvantagespt_PT
dc.subjectLimitationspt_PT
dc.subjectRecent advancespt_PT
dc.titleMetabolomics analysis for biomarker discovery: advances and challengespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage271pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage257pt_PT
oaire.citation.titleCurrent Medicinal Chemistrypt_PT
oaire.citation.volume20pt_PT
person.familyNameCarvalho
person.givenNameMarcia
person.identifier2017111
person.identifier.ciencia-id8B10-171E-E63E
person.identifier.orcid0000-0001-9884-4751
person.identifier.ridD-5999-2013
person.identifier.scopus-author-id7201413997
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3837b828-ba57-47f7-a811-cce65e4922c6
relation.isAuthorOfPublication.latestForDiscovery3837b828-ba57-47f7-a811-cce65e4922c6

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