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Design of a lipid nanovesicle system encapsulating bacteriophages integrated in a multiple emulsion formulation: A proof-of-concept

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dc.contributor.authorBalcão, V. M.
dc.contributor.authorAzevedo, A.F.
dc.contributor.authorCastro, L.M.
dc.contributor.authorCosta, Carla Isabel
dc.contributor.authorSantos, S. R. B.
dc.contributor.authorMatos, C. M.
dc.contributor.authorMoutinho, C. G.
dc.contributor.authorTeixeira, J. A.
dc.date.accessioned2019-12-24T12:33:33Z
dc.date.available2019-12-24T12:33:33Z
dc.date.issued2010
dc.description.abstractDevelopment of a biotechnological process for the inhalational administration of a bacteriophage was pursued, using strategies of nanoencapsulation within lipid nanovesicles. As a proof-of-concept for the nanoencapsulation strategy, a bacteriophage with broad lytic spectrum was entrapped within W/O/W multiple nanoemulsions. Physicochemical characterization of the optimized bacteriophage-encasing nanovesicles encompassed determination of particle hydrodynamic size, size distribution and particle charge via DLS, surface morphology via CRYO-SEM, and thermal analysis via DSC, whereas antimicrobial activity of the nanoemulsions produced was assessed in vitro using several bacterial strains. The optimized nanosystems showed no phase separation and encompassed nanovesicles with an average size of ca. 114 nm and an average Zeta Potential of ca. -13 mV, which were maintained stable over a storage timeframe of ca. 3 months.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBalcão, V. M.; Azevedo, A. F.; Castro, L. M.; Costa, C. I.; Santos, S.; Matos, C. M.; Moutinho, C.; Teixeira, J. A.; Azeredo, Joana, Design of a lipid nanovesicle system encapsulating bacteriophages integrated in a multiple emulsion formulation: A proof-of-concept. Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010. Vol. 3, Anheim, June 21-24, 459-462, 2010. ISBN: 978-1-4398-3415-2pt_PT
dc.identifier.isbn978-1-4398-3415-2
dc.identifier.urihttp://hdl.handle.net/10284/8342
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBacteriophagespt_PT
dc.subjectAntibiotherapypt_PT
dc.subjectMultiple emulsionspt_PT
dc.subjectNanoencapsulationpt_PT
dc.titleDesign of a lipid nanovesicle system encapsulating bacteriophages integrated in a multiple emulsion formulation: A proof-of-conceptpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.endPage462pt_PT
oaire.citation.startPage459pt_PT
oaire.citation.titleNanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010, Chapter 7: Nano Medical Sciencespt_PT
oaire.citation.volume3pt_PT
person.familyNameBalcão
person.familyNameMatos
person.familyNameMoutinho
person.givenNameVictor
person.givenNameCarla
person.givenNameCarla
person.identifier366700
person.identifier1536969
person.identifier.ciencia-idC314-A18C-931B
person.identifier.ciencia-id721C-DA34-256E
person.identifier.ciencia-idB61F-F356-80C6
person.identifier.orcid0000-0003-0772-2834
person.identifier.orcid0000-0003-0617-3538
person.identifier.orcid0000-0003-1310-4696
person.identifier.ridI-2182-2012
person.identifier.ridM-7142-2013
person.identifier.scopus-author-id6603449856
person.identifier.scopus-author-id7004493818
person.identifier.scopus-author-id16064733800
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicationf84a6560-46a5-4a51-91e4-25ab97dd1319
relation.isAuthorOfPublicationd4b6d3e1-6d29-4fb4-97c7-abb2cf4c83b4
relation.isAuthorOfPublicationcff7638e-1f33-4384-aa73-d3acc5cca5f8
relation.isAuthorOfPublication.latestForDiscoveryf84a6560-46a5-4a51-91e4-25ab97dd1319

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