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Mechanisms underlying the hepatotoxic effects of ecstasy

2010Journal article Restricted access
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dc.contributor.authorCarvalho, Márcia
dc.contributor.authorPontes, Helena
dc.contributor.authorRemiao, Fernando
dc.contributor.authorBastos, Maria L.
dc.contributor.authorCarvalho, Felix
dc.date.accessioned2021-07-05T08:45:52Z
dc.date.available2021-07-05T08:45:52Z
dc.date.issued2010
dc.description.abstract3,4-Methylenedioxymethamphetamine (MDMA or ecstasy) is a worldwide illegally used amphetamine-derived designer drug known to be hepatotoxic to humans. Jaundice, hepatomegaly, centrilobular necrosis, hepatitis and fibrosis represent some of the adverse effects caused by MDMA in the liver. Although there is irrefutable evidence of MDMA-induced hepatocellular damage, the mechanisms responsible for that toxicity remain to be thoroughly clarified. One well thought-of mechanism imply MDMA metabolism in the liver into reactive metabolites as responsible for the MDMA-elicited hepatotoxicity. However, other factors, including MDMA-induced hyperthermia, the increase in neurotransmitters efflux, the oxidation of biogenic amines, polydrug abuse pattern, and environmental features accompanying illicit MDMA use, may increase the risk for liver complications. Liver damage patterns of MDMA in animals and humans and current research on the mechanisms underlying the hepatotoxic effects of MDMA will be highlighted in this review.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.2174/138920110791591535pt_PT
dc.identifier.issn1389-2010
dc.identifier.urihttp://hdl.handle.net/10284/10048
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBentham Science Publisherspt_PT
dc.subjectEcstasypt_PT
dc.subjectMDMApt_PT
dc.subjectHepatotoxicitpt_PT
dc.subjectLiver damagept_PT
dc.subjectMechanismspt_PT
dc.titleMechanisms underlying the hepatotoxic effects of ecstasypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage495pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage476pt_PT
oaire.citation.titleCurrent Pharmaceutical Biotechnologypt_PT
oaire.citation.volume11pt_PT
person.familyNameCarvalho
person.givenNameMarcia
person.identifier2017111
person.identifier.ciencia-id8B10-171E-E63E
person.identifier.orcid0000-0001-9884-4751
person.identifier.ridD-5999-2013
person.identifier.scopus-author-id7201413997
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3837b828-ba57-47f7-a811-cce65e4922c6
relation.isAuthorOfPublication.latestForDiscovery3837b828-ba57-47f7-a811-cce65e4922c6

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